Metalloproteinase Inhibitors: Status and Scope from Marine Organisms
Marine environment has been the source of diverse life forms that produce different biologically active compounds. Marine organisms are consistently contributing with unparalleled bioactive compounds that have profound applications in nutraceuticals, cosmeceuticals, and pharmaceuticals. In this proc...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2010/845975 |
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| author | Noel Vinay Thomas Se-Kwon Kim |
| author_facet | Noel Vinay Thomas Se-Kwon Kim |
| author_sort | Noel Vinay Thomas |
| collection | DOAJ |
| description | Marine environment has been the source of diverse life forms that produce different biologically active compounds. Marine organisms are consistently contributing with unparalleled bioactive compounds that have profound applications in nutraceuticals, cosmeceuticals, and pharmaceuticals. In this process, screening of natural products from marine organisms that could potentially inhibit the expression of metalloproteinases has gained a huge popularity, which became a hot field of research in life sciences. Metalloproteinases, especially, matrix metalloproteinases (MMPs) are a class of structurally similar enzymes that contribute to the extracellular matrix degradation and play major role in normal and pathological tissue remodeling. Imbalance in the expression of MMPs leads to severe pathological condition that could initiate cardiac, cartilage, and cancer-related diseases. Three decades of endeavor for designing potent matrix metalloproteinase inhibitory substances (MMPIs) with many not making upto final clinical trials seek new resources for devising MMPIs. Umpteen number of medicinally valuable compounds being reported from marine organisms, which encourage current researchers to screen potent MMPIs from marine organisms. In this paper, we have made an attempt to report the metalloproteinase inhibiting substances from various marine organisms. |
| format | Article |
| id | doaj-art-5126e7668d674629b4d63d99707d8c35 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-5126e7668d674629b4d63d99707d8c352025-02-03T05:47:46ZengWileyBiochemistry Research International2090-22472090-22552010-01-01201010.1155/2010/845975845975Metalloproteinase Inhibitors: Status and Scope from Marine OrganismsNoel Vinay Thomas0Se-Kwon Kim1Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of KoreaMarine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of KoreaMarine environment has been the source of diverse life forms that produce different biologically active compounds. Marine organisms are consistently contributing with unparalleled bioactive compounds that have profound applications in nutraceuticals, cosmeceuticals, and pharmaceuticals. In this process, screening of natural products from marine organisms that could potentially inhibit the expression of metalloproteinases has gained a huge popularity, which became a hot field of research in life sciences. Metalloproteinases, especially, matrix metalloproteinases (MMPs) are a class of structurally similar enzymes that contribute to the extracellular matrix degradation and play major role in normal and pathological tissue remodeling. Imbalance in the expression of MMPs leads to severe pathological condition that could initiate cardiac, cartilage, and cancer-related diseases. Three decades of endeavor for designing potent matrix metalloproteinase inhibitory substances (MMPIs) with many not making upto final clinical trials seek new resources for devising MMPIs. Umpteen number of medicinally valuable compounds being reported from marine organisms, which encourage current researchers to screen potent MMPIs from marine organisms. In this paper, we have made an attempt to report the metalloproteinase inhibiting substances from various marine organisms.http://dx.doi.org/10.1155/2010/845975 |
| spellingShingle | Noel Vinay Thomas Se-Kwon Kim Metalloproteinase Inhibitors: Status and Scope from Marine Organisms Biochemistry Research International |
| title | Metalloproteinase Inhibitors: Status and Scope from Marine Organisms |
| title_full | Metalloproteinase Inhibitors: Status and Scope from Marine Organisms |
| title_fullStr | Metalloproteinase Inhibitors: Status and Scope from Marine Organisms |
| title_full_unstemmed | Metalloproteinase Inhibitors: Status and Scope from Marine Organisms |
| title_short | Metalloproteinase Inhibitors: Status and Scope from Marine Organisms |
| title_sort | metalloproteinase inhibitors status and scope from marine organisms |
| url | http://dx.doi.org/10.1155/2010/845975 |
| work_keys_str_mv | AT noelvinaythomas metalloproteinaseinhibitorsstatusandscopefrommarineorganisms AT sekwonkim metalloproteinaseinhibitorsstatusandscopefrommarineorganisms |