Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions
Elizabethkingia miricola is a gram-negative bacillus, a life-threatening pathogen in humans and animals. Linalool, a naturally occurring monoterpene alcohol found in plant volatile oils, exhibits highly effective antibacterial properties. This study investigated the antibacterial activity and mechan...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517425000422 |
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| author | Mingwang He Weiming Zhong Rongsi Dai Su Long Ying Zhou Tongping Zhang Boyang Zhou Tao Tang Linlin Yang Sifan Jiang Wenbin Xiao YanJiao Fu Jiajing Guo Zhipeng Gao |
| author_facet | Mingwang He Weiming Zhong Rongsi Dai Su Long Ying Zhou Tongping Zhang Boyang Zhou Tao Tang Linlin Yang Sifan Jiang Wenbin Xiao YanJiao Fu Jiajing Guo Zhipeng Gao |
| author_sort | Mingwang He |
| collection | DOAJ |
| description | Elizabethkingia miricola is a gram-negative bacillus, a life-threatening pathogen in humans and animals. Linalool, a naturally occurring monoterpene alcohol found in plant volatile oils, exhibits highly effective antibacterial properties. This study investigated the antibacterial activity and mechanism of linalool against E. miricola. Initially, linalool showed potent antibacterial activity against E. miricola, with inhibition zone (ZOI), MIC, and MBC values of 36.41 ± 1.23 mm, 0.125 % (v/v, 1.0775 mg/mL), and 0.125 % (v/v, 1.0775 mg/mL), respectively. Secondly, it was observed by electron microscopy that linalool caused crumpling, depression, and size reduction of the cells. Linalool affected cell membrane integrity, causing membrane damage and rupture. Thirdly, transcriptome analysis suggested that linalool affected C5-branched-chain dicarboxylic acid metabolism and the biosynthesis of valine, leucine, and isoleucine, result in increased energy production to linalool stress. Linalool disrupted cell division and RNA function in E. miricola, and the cells responded to linalool-induced oxidative damage by up-regulating the expression of msrB and katG genes. Fourthly, metabolome analysis revealed an increase in metabolites related to the glycerophospholipid metabolic pathway and NADP content in E. miricola, which may be a metabolic response to linalool stress. Taken together, these findings provide a theoretical basis for the antibacterial mechanism of linalool and suggest potential applications for preventing E. miricola infections. |
| format | Article |
| id | doaj-art-511ea14a1086487993d832ca4d565052 |
| institution | DOAJ |
| issn | 2666-5174 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-511ea14a1086487993d832ca4d5650522025-08-20T03:10:42ZengElsevierCurrent Research in Microbial Sciences2666-51742025-01-01810038010.1016/j.crmicr.2025.100380Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functionsMingwang He0Weiming Zhong1Rongsi Dai2Su Long3Ying Zhou4Tongping Zhang5Boyang Zhou6Tao Tang7Linlin Yang8Sifan Jiang9Wenbin Xiao10YanJiao Fu11Jiajing Guo12Zhipeng Gao13Fisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaFisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, ChinaHunan Agriculture Product Processing Institute, Dongting Laboratory; International Joint Lab on Fruits &Vegetables Processing, Quality and Safety; Hunan Provincial Key Laboratory of Fruits &Vegetables Storage, Processing, Quality and Safety; Hunan Academy of Agricultural Sciences, Changsha 410125, Hunan Province, ChinaHunan Agriculture Product Processing Institute, Dongting Laboratory; International Joint Lab on Fruits &Vegetables Processing, Quality and Safety; Hunan Provincial Key Laboratory of Fruits &Vegetables Storage, Processing, Quality and Safety; Hunan Academy of Agricultural Sciences, Changsha 410125, Hunan Province, ChinaHunan Agriculture Product Processing Institute, Dongting Laboratory; International Joint Lab on Fruits &Vegetables Processing, Quality and Safety; Hunan Provincial Key Laboratory of Fruits &Vegetables Storage, Processing, Quality and Safety; Hunan Academy of Agricultural Sciences, Changsha 410125, Hunan Province, China; Corresponding authors.Fisheries College, Hunan Agricultural University, Changsha 410128, Hunan Province, China; Corresponding authors.Elizabethkingia miricola is a gram-negative bacillus, a life-threatening pathogen in humans and animals. Linalool, a naturally occurring monoterpene alcohol found in plant volatile oils, exhibits highly effective antibacterial properties. This study investigated the antibacterial activity and mechanism of linalool against E. miricola. Initially, linalool showed potent antibacterial activity against E. miricola, with inhibition zone (ZOI), MIC, and MBC values of 36.41 ± 1.23 mm, 0.125 % (v/v, 1.0775 mg/mL), and 0.125 % (v/v, 1.0775 mg/mL), respectively. Secondly, it was observed by electron microscopy that linalool caused crumpling, depression, and size reduction of the cells. Linalool affected cell membrane integrity, causing membrane damage and rupture. Thirdly, transcriptome analysis suggested that linalool affected C5-branched-chain dicarboxylic acid metabolism and the biosynthesis of valine, leucine, and isoleucine, result in increased energy production to linalool stress. Linalool disrupted cell division and RNA function in E. miricola, and the cells responded to linalool-induced oxidative damage by up-regulating the expression of msrB and katG genes. Fourthly, metabolome analysis revealed an increase in metabolites related to the glycerophospholipid metabolic pathway and NADP content in E. miricola, which may be a metabolic response to linalool stress. Taken together, these findings provide a theoretical basis for the antibacterial mechanism of linalool and suggest potential applications for preventing E. miricola infections.http://www.sciencedirect.com/science/article/pii/S2666517425000422E. miricolaLinaloolAntibacterial activityTranscriptomic analysisMetabolomic analysis |
| spellingShingle | Mingwang He Weiming Zhong Rongsi Dai Su Long Ying Zhou Tongping Zhang Boyang Zhou Tao Tang Linlin Yang Sifan Jiang Wenbin Xiao YanJiao Fu Jiajing Guo Zhipeng Gao Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions Current Research in Microbial Sciences E. miricola Linalool Antibacterial activity Transcriptomic analysis Metabolomic analysis |
| title | Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions |
| title_full | Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions |
| title_fullStr | Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions |
| title_full_unstemmed | Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions |
| title_short | Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions |
| title_sort | linalool exhibit antimicrobial ability against elizabethkingia miricola by disrupting cellular and metabolic functions |
| topic | E. miricola Linalool Antibacterial activity Transcriptomic analysis Metabolomic analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2666517425000422 |
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