TMBocelot: an omnibus statistical control model optimizing the TMB thresholds with systematic measurement errors

TMBocelot: an omnibus statistical control model optimizing the TMB thresholds with systematic measurement errors

Tumor mutation burden (TMB), defined as the number of somatic mutations of tumor DNA, is a well-recognized immunotherapy biomarker endorsed by regulatory agencies and pivotal in stratifying patients for clinical decision-making. However, measurement errors can compromise the accuracy of TMB assessme...

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Bibliographic Details
Main Authors: Xin Lai, Shaoliang Wang, Xuanping Zhang, Xiaoyan Zhu, Yuqian Liu, Zhili Chang, Xiaonan Wang, Yang Shao, Jiayin Wang, Yixuan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
tumor mutation burden
immunotherapy endpoints
pairwise error control
positive-threshold optimization
Bayesian framework
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1514295/full
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