Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation
The family of Toll-like receptors (TLRs) function as pattern-recognition receptors (PRRs) that respond to a myriad of highly conserved ligands. These substrates include pathogen-associated molecular patterns (PAMPs) for the recognition of invading pathogens, as well as damage-associated molecular pa...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/537263 |
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| _version_ | 1832548116105003008 |
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| author | John Evankovich Timothy Billiar Allan Tsung |
| author_facet | John Evankovich Timothy Billiar Allan Tsung |
| author_sort | John Evankovich |
| collection | DOAJ |
| description | The family of Toll-like receptors (TLRs) function as pattern-recognition receptors (PRRs) that respond to a myriad of highly conserved ligands. These substrates include pathogen-associated molecular patterns (PAMPs) for the recognition of invading pathogens, as well as damage-associated molecular patterns (DAMPs) for the recognition of endogenous tissue injury. While the functions of TLRs are diverse, they have received much attention for their roles in ischemia/reperfusion (I/R) injury of the liver and other organs. The TLRs play central roles in sensing tissue damage and activating the innate immune system following I/R. Engagement of TLRs by endogenous DAMPs activates proinflammatory signaling pathways leading to the production of cytokines, chemokines and further release of endogenous danger signals. This paper focuses on the most recent findings regarding TLR family members in hepatic I/R injury and transplantation. |
| format | Article |
| id | doaj-art-51192db98fec4b18a8d6f5dbc6bdc184 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-51192db98fec4b18a8d6f5dbc6bdc1842025-02-03T06:42:14ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/537263537263Toll-Like Receptors in Hepatic Ischemia/Reperfusion and TransplantationJohn Evankovich0Timothy Billiar1Allan Tsung2Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USADepartment of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USADepartment of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USAThe family of Toll-like receptors (TLRs) function as pattern-recognition receptors (PRRs) that respond to a myriad of highly conserved ligands. These substrates include pathogen-associated molecular patterns (PAMPs) for the recognition of invading pathogens, as well as damage-associated molecular patterns (DAMPs) for the recognition of endogenous tissue injury. While the functions of TLRs are diverse, they have received much attention for their roles in ischemia/reperfusion (I/R) injury of the liver and other organs. The TLRs play central roles in sensing tissue damage and activating the innate immune system following I/R. Engagement of TLRs by endogenous DAMPs activates proinflammatory signaling pathways leading to the production of cytokines, chemokines and further release of endogenous danger signals. This paper focuses on the most recent findings regarding TLR family members in hepatic I/R injury and transplantation.http://dx.doi.org/10.1155/2010/537263 |
| spellingShingle | John Evankovich Timothy Billiar Allan Tsung Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation Gastroenterology Research and Practice |
| title | Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation |
| title_full | Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation |
| title_fullStr | Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation |
| title_full_unstemmed | Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation |
| title_short | Toll-Like Receptors in Hepatic Ischemia/Reperfusion and Transplantation |
| title_sort | toll like receptors in hepatic ischemia reperfusion and transplantation |
| url | http://dx.doi.org/10.1155/2010/537263 |
| work_keys_str_mv | AT johnevankovich tolllikereceptorsinhepaticischemiareperfusionandtransplantation AT timothybilliar tolllikereceptorsinhepaticischemiareperfusionandtransplantation AT allantsung tolllikereceptorsinhepaticischemiareperfusionandtransplantation |