Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study.

Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study.

<h4>Objective</h4>To evaluate improvement in survival of lymphoma patients from 1990 to 2014, stratified by age, sex and race using Surveillance Epidemiology and End-Result Survey Program (SEER) data.<h4>Study design and setting</h4>We identified 113,788 incident lymphoma cas...

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Main Authors: Fahad Mukhtar, Paolo Boffetta, Bashir Dabo, Jong Y Park, Chi T D Tran, Thuan V Tran, Huong Thi-Thanh Tran, Madison Whitney, Harvey A Risch, Linh C Le, Wei Zheng, Xiao-Ou Shu, Hung N Luu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0199745
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Summary:<h4>Objective</h4>To evaluate improvement in survival of lymphoma patients from 1990 to 2014, stratified by age, sex and race using Surveillance Epidemiology and End-Result Survey Program (SEER) data.<h4>Study design and setting</h4>We identified 113,788 incident lymphoma cases from nine SEER cancer registries were followed up for cause-specific mortality from lymphoma. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and their respective 95% confidence interval (CIs) for various time periods within groups stratified by race, age and sex.<h4>Results</h4>Five-year survival for Hodgkin's lymphoma (HL) was 89% for patients 20-49 years of age. For this age group, compared to 1990-1994, survival significantly improved in 2000-2004 (HR = 0.65; 95% CI: 0.54-0.78), 2005-2009 (HR = 0.46, 95% CI: 0.38-0.57) and 2010-2014 (HR = 0.29, 95% CI: 0.20-0.41). Hodgkin's lymphoma patients aged 75-85 years had 5-year survival of 37% and in these patients, compared to 1990-1994, survival only improved from 2005 onward (HR = 0.67, 95% CI: 0.50-0.90). In patients with non-Hodgkin's Lymphoma (NHL), all age groups showed survival improvements between 1990-1994 period and 2010-2014 period. Improvements in HL and NHL survival were seen for all race categories and both genders.<h4>Conclusion</h4>Survival among US lymphoma patients has improved substantially between 1990-1994 period and 2010-2014 period, though disease-specific mortality was still higher in older age groups.
ISSN:1932-6203

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