Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration
Glucosinolates (GSLs) are nitrogen/sulfur-containing glycosides widely present in the order of Brassicales, particularly in the Brassicaceae family. Camelina (<i>Camelina sativa</i> (L.) Crantz) is an oilseed plant belonging to this family. Its seeds, in addition to a distinctive fatty a...
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2025-01-01
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author | Francesco Abbiati Ivan Orlandi Stefania Pagliari Luca Campone Marina Vai |
author_facet | Francesco Abbiati Ivan Orlandi Stefania Pagliari Luca Campone Marina Vai |
author_sort | Francesco Abbiati |
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description | Glucosinolates (GSLs) are nitrogen/sulfur-containing glycosides widely present in the order of Brassicales, particularly in the Brassicaceae family. Camelina (<i>Camelina sativa</i> (L.) Crantz) is an oilseed plant belonging to this family. Its seeds, in addition to a distinctive fatty acid composition, contain three aliphatic GSLs: glucoarabin, glucocamelinin, and homoglucocamelinin. Our study explored the impact of these GSLs purified from Camelina press cake, a by-product of Camelina oil production, on yeast chronological aging, which is the established model for simulating the aging of post-mitotic quiescent mammalian cells. Supplementing yeast cells with GSLs extends the chronological lifespan (CLS) in a dose-dependent manner. This enhancement relies on an improved mitochondrial respiration efficiency, resulting in a drastic decrease of superoxide anion levels and an increase in ATP production. Furthermore, GSL supplementation affects carbon metabolism. In particular, GSLs support the pro-longevity preservation of TCA cycle enzymatic activities and enhanced glycerol catabolism. These changes contribute positively to the phosphorylating respiration and to an increase in trehalose storage: both of which are longevity-promoting prerequisites. |
format | Article |
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institution | Kabale University |
issn | 2076-3921 |
language | English |
publishDate | 2025-01-01 |
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series | Antioxidants |
spelling | doaj-art-51088f445e3c40d4955a3c7688c418402025-01-24T13:19:25ZengMDPI AGAntioxidants2076-39212025-01-011418010.3390/antiox14010080Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and RespirationFrancesco Abbiati0Ivan Orlandi1Stefania Pagliari2Luca Campone3Marina Vai4Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyDipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyDipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyDipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyDipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyGlucosinolates (GSLs) are nitrogen/sulfur-containing glycosides widely present in the order of Brassicales, particularly in the Brassicaceae family. Camelina (<i>Camelina sativa</i> (L.) Crantz) is an oilseed plant belonging to this family. Its seeds, in addition to a distinctive fatty acid composition, contain three aliphatic GSLs: glucoarabin, glucocamelinin, and homoglucocamelinin. Our study explored the impact of these GSLs purified from Camelina press cake, a by-product of Camelina oil production, on yeast chronological aging, which is the established model for simulating the aging of post-mitotic quiescent mammalian cells. Supplementing yeast cells with GSLs extends the chronological lifespan (CLS) in a dose-dependent manner. This enhancement relies on an improved mitochondrial respiration efficiency, resulting in a drastic decrease of superoxide anion levels and an increase in ATP production. Furthermore, GSL supplementation affects carbon metabolism. In particular, GSLs support the pro-longevity preservation of TCA cycle enzymatic activities and enhanced glycerol catabolism. These changes contribute positively to the phosphorylating respiration and to an increase in trehalose storage: both of which are longevity-promoting prerequisites.https://www.mdpi.com/2076-3921/14/1/80Camelinaglucosinolateschronological aging<i>Saccharomyces cerevisiae</i>carbon metabolismrespiration |
spellingShingle | Francesco Abbiati Ivan Orlandi Stefania Pagliari Luca Campone Marina Vai Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration Antioxidants Camelina glucosinolates chronological aging <i>Saccharomyces cerevisiae</i> carbon metabolism respiration |
title | Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration |
title_full | Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration |
title_fullStr | Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration |
title_full_unstemmed | Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration |
title_short | Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration |
title_sort | glucosinolates from seed press cake of i camelina sativa i l crantz extend yeast chronological lifespan by modulating carbon metabolism and respiration |
topic | Camelina glucosinolates chronological aging <i>Saccharomyces cerevisiae</i> carbon metabolism respiration |
url | https://www.mdpi.com/2076-3921/14/1/80 |
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