Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries
Abstract Evaluate the prognostic performance of the lactate-to-albumin ratio (LAR) for complications in children 5 years of age or younger with second and/or third degree burn injuries during hospitalization in the intensive care unit of a hospital in Lima, Peru. In this retrospective cohort study,...
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Nature Portfolio
2025-01-01
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| author | Vania Cadarso-Saez Camila Ramirez-Zavala Miguel A. Pérez-Pino Carlos J. Toro-Huamanchumo |
| author_facet | Vania Cadarso-Saez Camila Ramirez-Zavala Miguel A. Pérez-Pino Carlos J. Toro-Huamanchumo |
| author_sort | Vania Cadarso-Saez |
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| description | Abstract Evaluate the prognostic performance of the lactate-to-albumin ratio (LAR) for complications in children 5 years of age or younger with second and/or third degree burn injuries during hospitalization in the intensive care unit of a hospital in Lima, Peru. In this retrospective cohort study, we conducted prognostic tests by analyzing the medical records of children aged ≤ 5 years who suffered second- and/or third-degree burn injuries and were subsequently admitted to the ICU of a Lima-based hospital between 2017 and 2022. The LAR was calculated using lactate and albumin values measured within the first 48 h post-burn. The area under the curve (AUC) was utilized to evaluate the prognostic performance of the LAR in predicting complications. A cohort of 258 patients aged ≤ 5 years with second- and/or third-degree burn injuries was examined. Among them, 63 patients experienced complications (24.4%). The estimated AUC ROC for the LAR was 0.63 (95% confidence interval [CI]: 0.54–0.71). After adjusting for confounders, values of LAR above the threshold were found to be associated with a significantly increased risk of complications (adjusted relative risk: 2.23; 95% CI 1.51–3.29; p < 0.001). The LAR exhibited limited prognostic capability for complications in pediatric burn patients. Nevertheless, a significant association was observed between values of LAR above the threshold and increased risk of complications. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-510556b1acf0479a8e04dee8153316792025-01-26T12:25:46ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-86614-7Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuriesVania Cadarso-Saez0Camila Ramirez-Zavala1Miguel A. Pérez-Pino2Carlos J. Toro-Huamanchumo3School of Medicine, Universidad Peruana de Ciencias AplicadasSchool of Medicine, Universidad Peruana de Ciencias AplicadasInstituto Nacional de Salud del Niño San BorjaUnidad de Investigación Para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de LoyolaAbstract Evaluate the prognostic performance of the lactate-to-albumin ratio (LAR) for complications in children 5 years of age or younger with second and/or third degree burn injuries during hospitalization in the intensive care unit of a hospital in Lima, Peru. In this retrospective cohort study, we conducted prognostic tests by analyzing the medical records of children aged ≤ 5 years who suffered second- and/or third-degree burn injuries and were subsequently admitted to the ICU of a Lima-based hospital between 2017 and 2022. The LAR was calculated using lactate and albumin values measured within the first 48 h post-burn. The area under the curve (AUC) was utilized to evaluate the prognostic performance of the LAR in predicting complications. A cohort of 258 patients aged ≤ 5 years with second- and/or third-degree burn injuries was examined. Among them, 63 patients experienced complications (24.4%). The estimated AUC ROC for the LAR was 0.63 (95% confidence interval [CI]: 0.54–0.71). After adjusting for confounders, values of LAR above the threshold were found to be associated with a significantly increased risk of complications (adjusted relative risk: 2.23; 95% CI 1.51–3.29; p < 0.001). The LAR exhibited limited prognostic capability for complications in pediatric burn patients. Nevertheless, a significant association was observed between values of LAR above the threshold and increased risk of complications.https://doi.org/10.1038/s41598-025-86614-7Lactate-to-albumin ratioBurnsPediatric patientsComplications |
| spellingShingle | Vania Cadarso-Saez Camila Ramirez-Zavala Miguel A. Pérez-Pino Carlos J. Toro-Huamanchumo Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries Scientific Reports Lactate-to-albumin ratio Burns Pediatric patients Complications |
| title | Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries |
| title_full | Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries |
| title_fullStr | Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries |
| title_full_unstemmed | Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries |
| title_short | Lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries |
| title_sort | lactate to albumin ratio has limited prognostic value for complications in children under five with burn injuries |
| topic | Lactate-to-albumin ratio Burns Pediatric patients Complications |
| url | https://doi.org/10.1038/s41598-025-86614-7 |
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