Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation
Purpose: To investigate changes in relative peripheral refraction (RPR) and their associations with axial length (AL) growth after one year of orthokeratology (ortho-k) therapy. Methods: This prospective cohort study included 60 myopic children aged 8–15 years. RPR and AL were measured at baseline a...
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Elsevier
2025-10-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025002716 |
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| author | Ke Wen Yifan Wu Bi Yang Longqian Liu |
| author_facet | Ke Wen Yifan Wu Bi Yang Longqian Liu |
| author_sort | Ke Wen |
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| description | Purpose: To investigate changes in relative peripheral refraction (RPR) and their associations with axial length (AL) growth after one year of orthokeratology (ortho-k) therapy. Methods: This prospective cohort study included 60 myopic children aged 8–15 years. RPR and AL were measured at baseline and 12 months after ortho-k therapy. Total RPR was measured via multispectral refraction topography (MRT) in the 53° fundus field of view, and then was divided into specific annuli (0–10°, 10–20°, 20–30°, 30–40°, 40–50° and 50–53°) and quadrants (superior, inferior, temporal and nasal). Linear regression analyses quantified associations between RPR changes and AL elongation. Results: Ultimately, 80.0 % of the participants were analysed. The total RPR was 0.64 ± 0.26 D at baseline and -0.35 ± 0.64 D at 12 months. Ortho-k therapy induced myopic shifts in all subregions (all p < 0.05). Additionally, hyperopic RPRs within the 50° region and in the superior, inferior and nasal parts of the retina became myopic. These myopes had an asymmetric RPR in the vertical retina both before and after ortho-k treatment but a symmetric RPR in the horizontal retina, which changed after treatment. Multivariate linear regression analyses revealed that the baseline AL and RPR changes in the 30–40° region and in the inferior retina were independently associated with AL elongation during one-year of ortho-k lens wear (all p < 0.05). Conclusions: The more myopic shifts of RPR induced by ortho-k treatment in the 30° to 40° region and in the inferior retina, the more effective control of axial elongation. |
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| institution | Kabale University |
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| language | English |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-50fa077818ff4aa587dfd040dc0329b12025-08-20T05:04:57ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-10-015510473910.1016/j.pdpdt.2025.104739Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongationKe Wen0Yifan Wu1Bi Yang2Longqian Liu3Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Optometry and Vision Sciences, West China Hospital, Sichuan University, Chengdu, China; Department of Optometry and Vision Sciences, West China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Optometry and Vision Sciences, West China Hospital, Sichuan University, Chengdu, China; Department of Optometry and Vision Sciences, West China School of Medicine, Sichuan University, Chengdu, China; Corresponding author at: Department of Ophthalmology, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Wuhou District, Chengdu, Sichuan 610041, China.Purpose: To investigate changes in relative peripheral refraction (RPR) and their associations with axial length (AL) growth after one year of orthokeratology (ortho-k) therapy. Methods: This prospective cohort study included 60 myopic children aged 8–15 years. RPR and AL were measured at baseline and 12 months after ortho-k therapy. Total RPR was measured via multispectral refraction topography (MRT) in the 53° fundus field of view, and then was divided into specific annuli (0–10°, 10–20°, 20–30°, 30–40°, 40–50° and 50–53°) and quadrants (superior, inferior, temporal and nasal). Linear regression analyses quantified associations between RPR changes and AL elongation. Results: Ultimately, 80.0 % of the participants were analysed. The total RPR was 0.64 ± 0.26 D at baseline and -0.35 ± 0.64 D at 12 months. Ortho-k therapy induced myopic shifts in all subregions (all p < 0.05). Additionally, hyperopic RPRs within the 50° region and in the superior, inferior and nasal parts of the retina became myopic. These myopes had an asymmetric RPR in the vertical retina both before and after ortho-k treatment but a symmetric RPR in the horizontal retina, which changed after treatment. Multivariate linear regression analyses revealed that the baseline AL and RPR changes in the 30–40° region and in the inferior retina were independently associated with AL elongation during one-year of ortho-k lens wear (all p < 0.05). Conclusions: The more myopic shifts of RPR induced by ortho-k treatment in the 30° to 40° region and in the inferior retina, the more effective control of axial elongation.http://www.sciencedirect.com/science/article/pii/S1572100025002716MyopiaRelative peripheral refractionOrthokeratologyMultispectral refraction topography |
| spellingShingle | Ke Wen Yifan Wu Bi Yang Longqian Liu Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation Photodiagnosis and Photodynamic Therapy Myopia Relative peripheral refraction Orthokeratology Multispectral refraction topography |
| title | Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation |
| title_full | Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation |
| title_fullStr | Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation |
| title_full_unstemmed | Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation |
| title_short | Novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one-year axial elongation |
| title_sort | novel quantitative analysis of relative peripheral refraction changes in orthokeratology and their relationship with one year axial elongation |
| topic | Myopia Relative peripheral refraction Orthokeratology Multispectral refraction topography |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025002716 |
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