Molecular dynamics of inflammation resolution: therapeutic implications
Inflammation is a critical part of innate immune response that is essential for exclusion of harmful stimuli and restoration of tissue homeostasis. Nonetheless, failure to resolve inflammation results in chronic inflammatory conditions, including autoimmune diseases. Conventionally, resolution of in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1600149/full |
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| author | Amro M. Soliman Mohamed Soliman Syed Sajid Hussain Shah Habeeb Ali Baig Nawal Salama Gouda Bandar Theyab Alenezi Awwad Alenezy Ahmed M. S. Hegazy Muhammad Jan Elhassan Hussein Eltom |
| author_facet | Amro M. Soliman Mohamed Soliman Syed Sajid Hussain Shah Habeeb Ali Baig Nawal Salama Gouda Bandar Theyab Alenezi Awwad Alenezy Ahmed M. S. Hegazy Muhammad Jan Elhassan Hussein Eltom |
| author_sort | Amro M. Soliman |
| collection | DOAJ |
| description | Inflammation is a critical part of innate immune response that is essential for exclusion of harmful stimuli and restoration of tissue homeostasis. Nonetheless, failure to resolve inflammation results in chronic inflammatory conditions, including autoimmune diseases. Conventionally, resolution of inflammation was deemed a passive process; however, evidence indicates that it entails active, highly regulated molecular and cellular events involving efferocytosis-driven macrophage reprogramming, post-transcriptional regulatory mechanisms and the production of specialized pro-resolving mediators (SPMs). These processes collectively restore tissue homeostasis and prevent chronic inflammation. Emerging therapeutic approaches targeting these pathways demonstrate promising results in preclinical studies and clinical trials, enhancing resolution and improving overall disease outcome. This resulted in a paradigm shift from conventional anti-inflammatory strategies to resolution-focused treatment. Yet, challenges remain due to the complexity of resolution mechanisms and tissue-specific differences. This review summarizes current advances in inflammation resolution, emphasizing emerging concepts of resolution pharmacology. By employing endogenous mechanisms facilitating resolution, novel therapeutic applications can effectively manage several chronic inflammatory disorders. |
| format | Article |
| id | doaj-art-50f9192812d64cf48ceb22ba2accfcc9 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-50f9192812d64cf48ceb22ba2accfcc92025-08-20T02:57:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-05-011310.3389/fcell.2025.16001491600149Molecular dynamics of inflammation resolution: therapeutic implicationsAmro M. Soliman0Mohamed Soliman1Syed Sajid Hussain Shah2Habeeb Ali Baig3Nawal Salama Gouda4Bandar Theyab Alenezi5Awwad Alenezy6Ahmed M. S. Hegazy7Muhammad Jan8Elhassan Hussein Eltom9Department of Biological Sciences, Faculty of Science, Concordia University of Edmonton, Edmonton, AB, CanadaDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Pathology, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Microbiology, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Family and Community Medicine, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Anatomy, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, Northern Border University, Arar, Saudi ArabiaInflammation is a critical part of innate immune response that is essential for exclusion of harmful stimuli and restoration of tissue homeostasis. Nonetheless, failure to resolve inflammation results in chronic inflammatory conditions, including autoimmune diseases. Conventionally, resolution of inflammation was deemed a passive process; however, evidence indicates that it entails active, highly regulated molecular and cellular events involving efferocytosis-driven macrophage reprogramming, post-transcriptional regulatory mechanisms and the production of specialized pro-resolving mediators (SPMs). These processes collectively restore tissue homeostasis and prevent chronic inflammation. Emerging therapeutic approaches targeting these pathways demonstrate promising results in preclinical studies and clinical trials, enhancing resolution and improving overall disease outcome. This resulted in a paradigm shift from conventional anti-inflammatory strategies to resolution-focused treatment. Yet, challenges remain due to the complexity of resolution mechanisms and tissue-specific differences. This review summarizes current advances in inflammation resolution, emphasizing emerging concepts of resolution pharmacology. By employing endogenous mechanisms facilitating resolution, novel therapeutic applications can effectively manage several chronic inflammatory disorders.https://www.frontiersin.org/articles/10.3389/fcell.2025.1600149/fullacute inflammationresolutionspecialized pro-resolving moleculesproinflammatory pathwaysresolution pharmacology |
| spellingShingle | Amro M. Soliman Mohamed Soliman Syed Sajid Hussain Shah Habeeb Ali Baig Nawal Salama Gouda Bandar Theyab Alenezi Awwad Alenezy Ahmed M. S. Hegazy Muhammad Jan Elhassan Hussein Eltom Molecular dynamics of inflammation resolution: therapeutic implications Frontiers in Cell and Developmental Biology acute inflammation resolution specialized pro-resolving molecules proinflammatory pathways resolution pharmacology |
| title | Molecular dynamics of inflammation resolution: therapeutic implications |
| title_full | Molecular dynamics of inflammation resolution: therapeutic implications |
| title_fullStr | Molecular dynamics of inflammation resolution: therapeutic implications |
| title_full_unstemmed | Molecular dynamics of inflammation resolution: therapeutic implications |
| title_short | Molecular dynamics of inflammation resolution: therapeutic implications |
| title_sort | molecular dynamics of inflammation resolution therapeutic implications |
| topic | acute inflammation resolution specialized pro-resolving molecules proinflammatory pathways resolution pharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1600149/full |
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