Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literature
Introduction: We present a rare case of uterine pilomatrix-like high grade endometrioid carcinoma (PiMHEC). We provide a thorough review of the 16 other PiMHEC cases reported to date, overview of our index case, and considerations for therapeutic approach with a focus on molecular subtyping. Case Su...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Gynecologic Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578925000189 |
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| author | L. Rusnell Z. Al-Shamma S.P. Bisch |
| author_facet | L. Rusnell Z. Al-Shamma S.P. Bisch |
| author_sort | L. Rusnell |
| collection | DOAJ |
| description | Introduction: We present a rare case of uterine pilomatrix-like high grade endometrioid carcinoma (PiMHEC). We provide a thorough review of the 16 other PiMHEC cases reported to date, overview of our index case, and considerations for therapeutic approach with a focus on molecular subtyping. Case Summary: This 44-year-old patient presented with widespread metastatic disease at time of diagnosis and initial clinical improvement with combination chemoradiotherapy. Immunotherapy was initiated later in the clinical course and the patient ultimately died of their disease 6 months post-diagnosis. Conclusion: Future clinicians may utilize PiMHEC case reports to formulate a therapeutic regimen and consider early initiation of immunotherapy. |
| format | Article |
| id | doaj-art-50f4d9f4fd024c6085ce366eafc29992 |
| institution | Kabale University |
| issn | 2352-5789 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj-art-50f4d9f4fd024c6085ce366eafc299922025-02-11T04:35:03ZengElsevierGynecologic Oncology Reports2352-57892025-02-0157101693Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literatureL. Rusnell0Z. Al-Shamma1S.P. Bisch2Corresponding author.; Foothills Medical Centre Calgary Alberta CanadaFoothills Medical Centre Calgary Alberta CanadaFoothills Medical Centre Calgary Alberta CanadaIntroduction: We present a rare case of uterine pilomatrix-like high grade endometrioid carcinoma (PiMHEC). We provide a thorough review of the 16 other PiMHEC cases reported to date, overview of our index case, and considerations for therapeutic approach with a focus on molecular subtyping. Case Summary: This 44-year-old patient presented with widespread metastatic disease at time of diagnosis and initial clinical improvement with combination chemoradiotherapy. Immunotherapy was initiated later in the clinical course and the patient ultimately died of their disease 6 months post-diagnosis. Conclusion: Future clinicians may utilize PiMHEC case reports to formulate a therapeutic regimen and consider early initiation of immunotherapy.http://www.sciencedirect.com/science/article/pii/S2352578925000189Endometrial cancerPilomatrix carcinomaMolecular subtypeChemotherapyImmunotherapyPathologic features |
| spellingShingle | L. Rusnell Z. Al-Shamma S.P. Bisch Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literature Gynecologic Oncology Reports Endometrial cancer Pilomatrix carcinoma Molecular subtype Chemotherapy Immunotherapy Pathologic features |
| title | Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literature |
| title_full | Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literature |
| title_fullStr | Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literature |
| title_full_unstemmed | Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literature |
| title_short | Uterine endometrioid adenocarcinoma with pilomatrix-like differentiation: A case report and review of the literature |
| title_sort | uterine endometrioid adenocarcinoma with pilomatrix like differentiation a case report and review of the literature |
| topic | Endometrial cancer Pilomatrix carcinoma Molecular subtype Chemotherapy Immunotherapy Pathologic features |
| url | http://www.sciencedirect.com/science/article/pii/S2352578925000189 |
| work_keys_str_mv | AT lrusnell uterineendometrioidadenocarcinomawithpilomatrixlikedifferentiationacasereportandreviewoftheliterature AT zalshamma uterineendometrioidadenocarcinomawithpilomatrixlikedifferentiationacasereportandreviewoftheliterature AT spbisch uterineendometrioidadenocarcinomawithpilomatrixlikedifferentiationacasereportandreviewoftheliterature |