Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings
In this study, new heterocyclic compounds were synthesized through the cyclization reactions of o-phenylenediamine (1) with various organic reagents. Benzodiazepine derivatives (2-4) were obtained by reaction of (1) with ethylacetoacetate, malonic acid and acetyl acetone.Treatment of compound (1) wi...
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University of Baghdad, College of Science for Women
2008-09-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/922 |
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| description | In this study, new heterocyclic compounds were synthesized through the cyclization reactions of o-phenylenediamine (1) with various organic reagents. Benzodiazepine derivatives (2-4) were obtained by reaction of (1) with ethylacetoacetate, malonic acid and acetyl acetone.Treatment of compound (1) with chloroacetamide, chloroacetic acid, p-bromophenacyl bromide and oxalic acid dihydrate afforded quinoxaline derivatives (5-8), respectively. Reaction of compound (1) with benzoic acid, piperonal, cyclohexanone and carbon disulfide resulted in the formation of compounds (9-12), respectively. Finally, reaction of compound (12) with chloroacetic acid in the presence of potassium hydroxide produced compound (13). |
| format | Article |
| id | doaj-art-50e67eaeb4074fa4be41ea5e496f1e03 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2008-09-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-50e67eaeb4074fa4be41ea5e496f1e032025-08-20T03:33:32ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862008-09-015310.21123/bsj.5.3.440-445Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole RingsBaghdad Science JournalIn this study, new heterocyclic compounds were synthesized through the cyclization reactions of o-phenylenediamine (1) with various organic reagents. Benzodiazepine derivatives (2-4) were obtained by reaction of (1) with ethylacetoacetate, malonic acid and acetyl acetone.Treatment of compound (1) with chloroacetamide, chloroacetic acid, p-bromophenacyl bromide and oxalic acid dihydrate afforded quinoxaline derivatives (5-8), respectively. Reaction of compound (1) with benzoic acid, piperonal, cyclohexanone and carbon disulfide resulted in the formation of compounds (9-12), respectively. Finally, reaction of compound (12) with chloroacetic acid in the presence of potassium hydroxide produced compound (13).http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/922"Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole, Cyclization Reactions" |
| spellingShingle | Baghdad Science Journal Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings مجلة بغداد للعلوم "Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole, Cyclization Reactions" |
| title | Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings |
| title_full | Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings |
| title_fullStr | Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings |
| title_full_unstemmed | Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings |
| title_short | Synthesis and Characterization of New Fused Heterocyclic Compounds Consisting of Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole Rings |
| title_sort | synthesis and characterization of new fused heterocyclic compounds consisting of benzodiazepine quinoxaline benzimidazole and thiazole rings |
| topic | "Benzodiazepine, Quinoxaline, Benzimidazole and Thiazole, Cyclization Reactions" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/922 |
| work_keys_str_mv | AT baghdadsciencejournal synthesisandcharacterizationofnewfusedheterocycliccompoundsconsistingofbenzodiazepinequinoxalinebenzimidazoleandthiazolerings |