Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia
Purpose: To investigate the relationship between ocular fundus abnormalities and cytokines in patients with severe viral pneumonia, aiming to provide targeted diagnostic recommendations. Methods: We assessed critically ill patients with severe viral pneumonia and categorized them into the survivor (...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Journal of Clinical Virology Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667038024000218 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825199253782265856 |
|---|---|
| author | Yun Yu Yun-jiao Zhao Qi-hang Zhou Xiao-yin Zhou Yu-qing Lan Hai-jun Gong |
| author_facet | Yun Yu Yun-jiao Zhao Qi-hang Zhou Xiao-yin Zhou Yu-qing Lan Hai-jun Gong |
| author_sort | Yun Yu |
| collection | DOAJ |
| description | Purpose: To investigate the relationship between ocular fundus abnormalities and cytokines in patients with severe viral pneumonia, aiming to provide targeted diagnostic recommendations. Methods: We assessed critically ill patients with severe viral pneumonia and categorized them into the survivor (17 patients, 33 eyes) and deceased (30 patients, 58 eyes) groups. Spearman's correlation analysis was used to assess associations between cytokine levels and fundus abnormalities. Results: In the deceased group, the vascular fractal dimension (FD) and vessel density (VD) were lower and negatively correlated with interleukin 2 (IL-2), IL-8, IL-10, interferon (IFN)-α, IFN-γ, IL-1β, IL-12, and IL-6 but positively correlated with IL-5. In the survivor group, arterial dilatation and reduced curvature were positively correlated with IL-6 and negatively correlated with IL-2 and IL-12; moreover, venous abnormalities were negatively correlated with IL-5, IL-10, and tumor necrosis factor (TNF)-α. In the deceased group, venous abnormalities were positively correlated with IL-10 and negatively correlated with IL-5, IL-1β, and TNF-α. The cup-to-disc ratio (CDR) was lower in the deceased group, with a significant reduction in rim width (RW), especially in the superior region. In the survivor group, the CDR was negatively correlated with IL-10, while in the deceased group, it was positively correlated with IL-6. RW was positively correlated with IL-1β, IL-5, and IL-10 in the survivor group and with IL-10, IL-12, and IL-17 in the deceased group. Conclusion: Fundus vascular abnormalities and optic disc edema are associated with cytokine levels in patients with severe viral pneumonia, with significant differences between survivors and deceased patients. |
| format | Article |
| id | doaj-art-50e2b81ae6b8464db88119ae457f31e6 |
| institution | Kabale University |
| issn | 2667-0380 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Virology Plus |
| spelling | doaj-art-50e2b81ae6b8464db88119ae457f31e62025-02-08T05:01:31ZengElsevierJournal of Clinical Virology Plus2667-03802025-02-0151100196Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumoniaYun Yu0Yun-jiao Zhao1Qi-hang Zhou2Xiao-yin Zhou3Yu-qing Lan4Hai-jun Gong5Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaDepartment of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaCorresponding authors.; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaCorresponding authors.; Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaPurpose: To investigate the relationship between ocular fundus abnormalities and cytokines in patients with severe viral pneumonia, aiming to provide targeted diagnostic recommendations. Methods: We assessed critically ill patients with severe viral pneumonia and categorized them into the survivor (17 patients, 33 eyes) and deceased (30 patients, 58 eyes) groups. Spearman's correlation analysis was used to assess associations between cytokine levels and fundus abnormalities. Results: In the deceased group, the vascular fractal dimension (FD) and vessel density (VD) were lower and negatively correlated with interleukin 2 (IL-2), IL-8, IL-10, interferon (IFN)-α, IFN-γ, IL-1β, IL-12, and IL-6 but positively correlated with IL-5. In the survivor group, arterial dilatation and reduced curvature were positively correlated with IL-6 and negatively correlated with IL-2 and IL-12; moreover, venous abnormalities were negatively correlated with IL-5, IL-10, and tumor necrosis factor (TNF)-α. In the deceased group, venous abnormalities were positively correlated with IL-10 and negatively correlated with IL-5, IL-1β, and TNF-α. The cup-to-disc ratio (CDR) was lower in the deceased group, with a significant reduction in rim width (RW), especially in the superior region. In the survivor group, the CDR was negatively correlated with IL-10, while in the deceased group, it was positively correlated with IL-6. RW was positively correlated with IL-1β, IL-5, and IL-10 in the survivor group and with IL-10, IL-12, and IL-17 in the deceased group. Conclusion: Fundus vascular abnormalities and optic disc edema are associated with cytokine levels in patients with severe viral pneumonia, with significant differences between survivors and deceased patients.http://www.sciencedirect.com/science/article/pii/S2667038024000218Critical illnessCytokineOcular fundusViral pneumonia |
| spellingShingle | Yun Yu Yun-jiao Zhao Qi-hang Zhou Xiao-yin Zhou Yu-qing Lan Hai-jun Gong Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia Journal of Clinical Virology Plus Critical illness Cytokine Ocular fundus Viral pneumonia |
| title | Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia |
| title_full | Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia |
| title_fullStr | Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia |
| title_full_unstemmed | Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia |
| title_short | Correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia |
| title_sort | correlation of cytokine storm with ocular fundus abnormalities in critically ill patients with severe viral pneumonia |
| topic | Critical illness Cytokine Ocular fundus Viral pneumonia |
| url | http://www.sciencedirect.com/science/article/pii/S2667038024000218 |
| work_keys_str_mv | AT yunyu correlationofcytokinestormwithocularfundusabnormalitiesincriticallyillpatientswithsevereviralpneumonia AT yunjiaozhao correlationofcytokinestormwithocularfundusabnormalitiesincriticallyillpatientswithsevereviralpneumonia AT qihangzhou correlationofcytokinestormwithocularfundusabnormalitiesincriticallyillpatientswithsevereviralpneumonia AT xiaoyinzhou correlationofcytokinestormwithocularfundusabnormalitiesincriticallyillpatientswithsevereviralpneumonia AT yuqinglan correlationofcytokinestormwithocularfundusabnormalitiesincriticallyillpatientswithsevereviralpneumonia AT haijungong correlationofcytokinestormwithocularfundusabnormalitiesincriticallyillpatientswithsevereviralpneumonia |