Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

Abstract Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs) by generating single-stranded DNA (ssDNA), which is initially coated by Replication Protein A (Rpa). Rad51, a recombinase, catalyzes strand invasion but binds ssDNA with lower affinity than Rpa, necessitating mediator p...

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Main Authors: Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monica Tokmina-Lukaszewska, Steven K. Gore, Jie Liu, Vikas Kaushik, Simrithaa Karunakaran, Angela Taddei, Wolf-Dietrich Heyer, Taekjip Ha, Brian Bothner, Edwin Antony
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61811-0
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