Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern China
Abstract Background The impacts of COVID-19 on acute myocardial infarction (AMI) care were heterogeneous. The study aims to analyze the clinical characteristics and outcomes of AMI patients in China during different stages of the COVID-19 pandemic. Methods This is a multicenter retrospective cohort...
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BMC
2025-03-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04686-9 |
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| author | Kang Li Yannan Pan Xiaojian Song Bin Yang Huifeng Wang Fan Yang Quanbao Liu Xinhong Lin Shuzhen Zhao Yuqi Yuan Ze Zhang Bin Zhang Fangfang Fan Dengfeng Ma |
| author_facet | Kang Li Yannan Pan Xiaojian Song Bin Yang Huifeng Wang Fan Yang Quanbao Liu Xinhong Lin Shuzhen Zhao Yuqi Yuan Ze Zhang Bin Zhang Fangfang Fan Dengfeng Ma |
| author_sort | Kang Li |
| collection | DOAJ |
| description | Abstract Background The impacts of COVID-19 on acute myocardial infarction (AMI) care were heterogeneous. The study aims to analyze the clinical characteristics and outcomes of AMI patients in China during different stages of the COVID-19 pandemic. Methods This is a multicenter retrospective cohort study in Shanxi Province of northern China. Patients diagnosed with AMI during the zero-case, lockdown, and outbreak periods were included. Characteristics and outcomes were analyzed according to time periods and COVID-19 infection. The primary outcome was in-hospital mortality. Additional outcomes included reperfusion times, coronary angiographic measures, procedure or AMI-associated complications, arrhythmia, other adverse events, and left ventricular systolic dysfunction (LVSD). Results The study included 1021 AMI patients, with 393, 250, and 378 from the zero-case, lockdown, and outbreak periods. No differences in in-hospital mortality or other adverse events were found by time periods. By infection status, 264 patients were COVID-positive, and 706 were COVID-negative. The COVID-positive ST-elevation myocardial infarction population had longer symptom-to-first medical contact (3.07 vs. 2.31, p = 0.026), pre-hospital time (4.58 vs. 3.67, p = 0.032), door-to-balloon (1.20 vs. 1.08, p = 0.046), and total ischemic time (5.80 vs. 4.70, p = 0.011). No differences in other in-hospital outcomes were found, except that multivariate logistic regression analysis demonstrated COVID-19 infection was correlated with increased risks of LVSD (OR 1.73, 95% CI 1.11–2.69, p = 0.015). Conclusions In-hospital mortality did not differ by time period or COVID-19 infection status. The COVID-positive AMI patients had longer reperfusion times and higher risks of LVSD. AMI treatments were impacted during the pandemic, and measures are warranted to minimize the reperfusion time. |
| format | Article |
| id | doaj-art-50de2681ec824bc49b0e2daadea19419 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-50de2681ec824bc49b0e2daadea194192025-08-20T03:40:47ZengBMCBMC Cardiovascular Disorders1471-22612025-03-0125111110.1186/s12872-025-04686-9Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern ChinaKang Li0Yannan Pan1Xiaojian Song2Bin Yang3Huifeng Wang4Fan Yang5Quanbao Liu6Xinhong Lin7Shuzhen Zhao8Yuqi Yuan9Ze Zhang10Bin Zhang11Fangfang Fan12Dengfeng Ma13Department of Cardiology, Peking University First HospitalDepartment of Cardiology, Peking University First HospitalDepartment of Cardiology, Shanxi Cardiovascular HospitalDepartment of Cardiology, Second Hospital of Shanxi Medical UniversityDepartment of Cardiology, Taigang General HospitalDepartment of Cardiology, Taiyuan Central HospitalDepartment of Cardiology, Shanxi Cardiovascular HospitalDepartment of Cardiology, Taiyuan Central HospitalDepartment of Cardiology, Taiyuan Central HospitalDepartment of Cardiology, Jincheng People’s HospitalThe Ninth School of clinical medicine, Shanxi Medical UniversityThe Ninth School of clinical medicine, Shanxi Medical UniversityDepartment of Cardiology, Peking University First HospitalDepartment of Cardiology, Taiyuan Central HospitalAbstract Background The impacts of COVID-19 on acute myocardial infarction (AMI) care were heterogeneous. The study aims to analyze the clinical characteristics and outcomes of AMI patients in China during different stages of the COVID-19 pandemic. Methods This is a multicenter retrospective cohort study in Shanxi Province of northern China. Patients diagnosed with AMI during the zero-case, lockdown, and outbreak periods were included. Characteristics and outcomes were analyzed according to time periods and COVID-19 infection. The primary outcome was in-hospital mortality. Additional outcomes included reperfusion times, coronary angiographic measures, procedure or AMI-associated complications, arrhythmia, other adverse events, and left ventricular systolic dysfunction (LVSD). Results The study included 1021 AMI patients, with 393, 250, and 378 from the zero-case, lockdown, and outbreak periods. No differences in in-hospital mortality or other adverse events were found by time periods. By infection status, 264 patients were COVID-positive, and 706 were COVID-negative. The COVID-positive ST-elevation myocardial infarction population had longer symptom-to-first medical contact (3.07 vs. 2.31, p = 0.026), pre-hospital time (4.58 vs. 3.67, p = 0.032), door-to-balloon (1.20 vs. 1.08, p = 0.046), and total ischemic time (5.80 vs. 4.70, p = 0.011). No differences in other in-hospital outcomes were found, except that multivariate logistic regression analysis demonstrated COVID-19 infection was correlated with increased risks of LVSD (OR 1.73, 95% CI 1.11–2.69, p = 0.015). Conclusions In-hospital mortality did not differ by time period or COVID-19 infection status. The COVID-positive AMI patients had longer reperfusion times and higher risks of LVSD. AMI treatments were impacted during the pandemic, and measures are warranted to minimize the reperfusion time.https://doi.org/10.1186/s12872-025-04686-9Acute myocardial infarctionCOVID-19In-hospital outcomesReperfusion time |
| spellingShingle | Kang Li Yannan Pan Xiaojian Song Bin Yang Huifeng Wang Fan Yang Quanbao Liu Xinhong Lin Shuzhen Zhao Yuqi Yuan Ze Zhang Bin Zhang Fangfang Fan Dengfeng Ma Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern China BMC Cardiovascular Disorders Acute myocardial infarction COVID-19 In-hospital outcomes Reperfusion time |
| title | Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern China |
| title_full | Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern China |
| title_fullStr | Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern China |
| title_full_unstemmed | Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern China |
| title_short | Clinical characteristics and outcomes of acute myocardial infarction during the COVID-19 pandemic: a multicenter retrospective cohort study in Northern China |
| title_sort | clinical characteristics and outcomes of acute myocardial infarction during the covid 19 pandemic a multicenter retrospective cohort study in northern china |
| topic | Acute myocardial infarction COVID-19 In-hospital outcomes Reperfusion time |
| url | https://doi.org/10.1186/s12872-025-04686-9 |
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