Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment
Summary: Metabolic syndrome (MetS) and mild cognitive impairment (MCI) are interconnected conditions sharing common pathological pathways, such as inflammation and oxidative stress, leading to the concept of “metabolic-cognitive syndrome.” This highlights their mutual influence and potential overlap...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225001087 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864236185485312 |
|---|---|
| author | Rebecca Sonnino Gea Ciccarelli Simona Moffa Laura Soldovieri Gianfranco Di Giuseppe Michela Brunetti Francesca Cinti Eleonora Di Piazza Antonio Gasbarrini Enrico C. Nista Alfredo Pontecorvi Andrea Giaccari Teresa Mezza |
| author_facet | Rebecca Sonnino Gea Ciccarelli Simona Moffa Laura Soldovieri Gianfranco Di Giuseppe Michela Brunetti Francesca Cinti Eleonora Di Piazza Antonio Gasbarrini Enrico C. Nista Alfredo Pontecorvi Andrea Giaccari Teresa Mezza |
| author_sort | Rebecca Sonnino |
| collection | DOAJ |
| description | Summary: Metabolic syndrome (MetS) and mild cognitive impairment (MCI) are interconnected conditions sharing common pathological pathways, such as inflammation and oxidative stress, leading to the concept of “metabolic-cognitive syndrome.” This highlights their mutual influence and potential overlapping therapeutic strategies. Although lifestyle modifications remain essential, nutraceutical supplementation has emerged as a promising adjunct for the prevention and management of these preclinical conditions. This review examines clinical and translational evidence on commonly used nutraceuticals targeting shared pathophysiological mechanisms of MetS and MCI. By addressing inflammation, oxidative stress, and metabolic dysfunction, these supplements may offer a valuable approach to mitigating the progression and consequences of both conditions. Understanding their efficacy could provide practical tools to complement lifestyle changes, offering a more comprehensive strategy for managing metabolic-cognitive syndrome. |
| format | Article |
| id | doaj-art-50dd9fbc4d3944218906e3fc9832afb0 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-50dd9fbc4d3944218906e3fc9832afb02025-02-09T05:00:59ZengElsevieriScience2589-00422025-02-01282111848Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairmentRebecca Sonnino0Gea Ciccarelli1Simona Moffa2Laura Soldovieri3Gianfranco Di Giuseppe4Michela Brunetti5Francesca Cinti6Eleonora Di Piazza7Antonio Gasbarrini8Enrico C. Nista9Alfredo Pontecorvi10Andrea Giaccari11Teresa Mezza12Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyCenter for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyCenter for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Pancreas Unit, CEMAD Digestive Diseases Center, Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, ItalyPancreas Unit, CEMAD Digestive Diseases Center, Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Corresponding authorDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; Pancreas Unit, CEMAD Digestive Diseases Center, Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Corresponding authorSummary: Metabolic syndrome (MetS) and mild cognitive impairment (MCI) are interconnected conditions sharing common pathological pathways, such as inflammation and oxidative stress, leading to the concept of “metabolic-cognitive syndrome.” This highlights their mutual influence and potential overlapping therapeutic strategies. Although lifestyle modifications remain essential, nutraceutical supplementation has emerged as a promising adjunct for the prevention and management of these preclinical conditions. This review examines clinical and translational evidence on commonly used nutraceuticals targeting shared pathophysiological mechanisms of MetS and MCI. By addressing inflammation, oxidative stress, and metabolic dysfunction, these supplements may offer a valuable approach to mitigating the progression and consequences of both conditions. Understanding their efficacy could provide practical tools to complement lifestyle changes, offering a more comprehensive strategy for managing metabolic-cognitive syndrome.http://www.sciencedirect.com/science/article/pii/S2589004225001087Cognitive neuroscienceHuman metabolism |
| spellingShingle | Rebecca Sonnino Gea Ciccarelli Simona Moffa Laura Soldovieri Gianfranco Di Giuseppe Michela Brunetti Francesca Cinti Eleonora Di Piazza Antonio Gasbarrini Enrico C. Nista Alfredo Pontecorvi Andrea Giaccari Teresa Mezza Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment iScience Cognitive neuroscience Human metabolism |
| title | Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment |
| title_full | Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment |
| title_fullStr | Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment |
| title_full_unstemmed | Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment |
| title_short | Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment |
| title_sort | exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment |
| topic | Cognitive neuroscience Human metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225001087 |
| work_keys_str_mv | AT rebeccasonnino exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT geaciccarelli exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT simonamoffa exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT laurasoldovieri exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT gianfrancodigiuseppe exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT michelabrunetti exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT francescacinti exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT eleonoradipiazza exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT antoniogasbarrini exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT enricocnista exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT alfredopontecorvi exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT andreagiaccari exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment AT teresamezza exploringnutraceuticalapproacheslinkingmetabolicsyndromeandcognitiveimpairment |