A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia
Introduction: One of the methods for pain management involves the use of local anesthesia, which numbs sensations in specific body regions while maintaining consciousness. Objectives: Considering the certain limitations (e.g., pain, the requirement of skilled professionals, or slow passive diffusion...
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Elsevier
2025-06-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123224003047 |
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| author | Xuequan Liu Xuequan Sun Hongyu Zhu Rubing Yan Chang Xu Fangxing Zhu Ruijie Xu Jing Xia He Dong Bingcheng Yi Qihui Zhou |
| author_facet | Xuequan Liu Xuequan Sun Hongyu Zhu Rubing Yan Chang Xu Fangxing Zhu Ruijie Xu Jing Xia He Dong Bingcheng Yi Qihui Zhou |
| author_sort | Xuequan Liu |
| collection | DOAJ |
| description | Introduction: One of the methods for pain management involves the use of local anesthesia, which numbs sensations in specific body regions while maintaining consciousness. Objectives: Considering the certain limitations (e.g., pain, the requirement of skilled professionals, or slow passive diffusion) of conventional delivery methods of local anesthetics, developing alternative strategies that offer minimally invasive yet therapeutically effective delivery systems is of great concern for ophthalmic regional anesthesia. Methods and results: In this study, a rapidly dissolving cambered microneedle (MNs) patch, composed of poly(vinylpyrrolidone) (PVP) and hyaluronic acid (HA) and served as a delivery system for lidocaine (Lido) in local anesthesia, was developed taking inspiration from the mosquito proboscis’s ability to extract blood unnoticed. The lidocaine-containing MNs patch (MNs@Lido) consisted of 25 microneedles with a four-pronged cone structure (height: 500 μm, base width: 275 μm), arranged in a concentric circle pattern on the patch, and displays excellent dissolubility for effective drug delivery of Lido. After confirming good cytocompatibility, MNs@Lido was found to possess adequate rigidity to penetrate the cornea without causing any subsequent injury, and the created corneal pinhole channels completely self-healed within 24 h. Interestingly, MNs@Lido exhibited effective analgesic effects for local anesthesia on both heel skin and eyeball, with the sustained anesthetic effect lasting for at least 30 min. Conclusions: These findings indicate that the mosquito proboscis-inspired cambered MNs patch provides rapid and painless local anesthesia, overcoming the limitations of conventional delivery methods of local anesthetics, thus opening up new possibilities in the treatment of ophthalmic diseases. |
| format | Article |
| id | doaj-art-50d9f51373a844e7adb3f322f23e6a0b |
| institution | OA Journals |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj-art-50d9f51373a844e7adb3f322f23e6a0b2025-08-20T02:33:14ZengElsevierJournal of Advanced Research2090-12322025-06-017260561410.1016/j.jare.2024.07.020A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesiaXuequan Liu0Xuequan Sun1Hongyu Zhu2Rubing Yan3Chang Xu4Fangxing Zhu5Ruijie Xu6Jing Xia7He Dong8Bingcheng Yi9Qihui Zhou10Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, School of Rehabilitation Science and Engineering, Qingdao 266113, China; Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, ChinaWeifang Eye Hospital, Zhengda Guangming Eye Group, Weifang 261041, China; Zhengda Guangming International Eye Research Center, Qingdao Zhengda Guangming Eye Hospital, Qingdao University, Qingdao 266000, ChinaDepartment of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, ChinaDepartment of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, ChinaWeifang Eye Hospital, Zhengda Guangming Eye Group, Weifang 261041, China; Zhengda Guangming International Eye Research Center, Qingdao Zhengda Guangming Eye Hospital, Qingdao University, Qingdao 266000, ChinaWeifang Eye Hospital, Zhengda Guangming Eye Group, Weifang 261041, China; Zhengda Guangming International Eye Research Center, Qingdao Zhengda Guangming Eye Hospital, Qingdao University, Qingdao 266000, ChinaSchool of Electronic Information, Qingdao University, Qingdao 266023, ChinaDepartment of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, ChinaDepartment of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, China; Corresponding author.Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, School of Rehabilitation Science and Engineering, Qingdao 266113, China; Corresponding author.Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, School of Rehabilitation Science and Engineering, Qingdao 266113, China; Corresponding author.Introduction: One of the methods for pain management involves the use of local anesthesia, which numbs sensations in specific body regions while maintaining consciousness. Objectives: Considering the certain limitations (e.g., pain, the requirement of skilled professionals, or slow passive diffusion) of conventional delivery methods of local anesthetics, developing alternative strategies that offer minimally invasive yet therapeutically effective delivery systems is of great concern for ophthalmic regional anesthesia. Methods and results: In this study, a rapidly dissolving cambered microneedle (MNs) patch, composed of poly(vinylpyrrolidone) (PVP) and hyaluronic acid (HA) and served as a delivery system for lidocaine (Lido) in local anesthesia, was developed taking inspiration from the mosquito proboscis’s ability to extract blood unnoticed. The lidocaine-containing MNs patch (MNs@Lido) consisted of 25 microneedles with a four-pronged cone structure (height: 500 μm, base width: 275 μm), arranged in a concentric circle pattern on the patch, and displays excellent dissolubility for effective drug delivery of Lido. After confirming good cytocompatibility, MNs@Lido was found to possess adequate rigidity to penetrate the cornea without causing any subsequent injury, and the created corneal pinhole channels completely self-healed within 24 h. Interestingly, MNs@Lido exhibited effective analgesic effects for local anesthesia on both heel skin and eyeball, with the sustained anesthetic effect lasting for at least 30 min. Conclusions: These findings indicate that the mosquito proboscis-inspired cambered MNs patch provides rapid and painless local anesthesia, overcoming the limitations of conventional delivery methods of local anesthetics, thus opening up new possibilities in the treatment of ophthalmic diseases.http://www.sciencedirect.com/science/article/pii/S2090123224003047Cambered microneedlesOphthalmic regional anaesthesiaDissolubilityLidocaineMosquito proboscis |
| spellingShingle | Xuequan Liu Xuequan Sun Hongyu Zhu Rubing Yan Chang Xu Fangxing Zhu Ruijie Xu Jing Xia He Dong Bingcheng Yi Qihui Zhou A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia Journal of Advanced Research Cambered microneedles Ophthalmic regional anaesthesia Dissolubility Lidocaine Mosquito proboscis |
| title | A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia |
| title_full | A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia |
| title_fullStr | A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia |
| title_full_unstemmed | A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia |
| title_short | A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia |
| title_sort | mosquito proboscis inspired cambered microneedle patch for ophthalmic regional anaesthesia |
| topic | Cambered microneedles Ophthalmic regional anaesthesia Dissolubility Lidocaine Mosquito proboscis |
| url | http://www.sciencedirect.com/science/article/pii/S2090123224003047 |
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