Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence.

Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence.

We examined the contribution of serotype on Streptococcus pneumoniae adhesion and virulence during respiratory tract infection using a panel of isogenic TIGR4 (serotype 4) mutants expressing the capsule types 6A (+6A), 7F (+7F) and 23F (+23F) as well as a deleted and restored serotype 4 (+4) control...

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Bibliographic Details
Main Authors: Carlos J Sanchez, Cecilia A Hinojosa, Pooja Shivshankar, Catherine Hyams, Emilie Camberlein, Jeremy S Brown, Carlos J Orihuela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026587&type=printable
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