TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models

TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models

Despite therapeutic efficacy observed with immune checkpoint blockade in advanced melanoma, many tumors do not respond to treatment, representing a need for new therapies. Here, we have generated chimeric antigen receptor (CAR) T cells targeting TYRP1, a melanoma differentiation antigen expressed on...

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Bibliographic Details
Main Authors: Christopher S. Hackett, Daniel Hirschhorn, Meixian S. Tang, Terence J. Purdon, Yacine Marouf, Alessandra Piersigilli, Narasimhan P. Agaram, Cailian Liu, Sara E. Schad, Elisa de Stanchina, Sarwish Rafiq, Sebastien Monette, Jedd D. Wolchok, Taha Merghoub, Renier J. Brentjens
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
melanoma
acral
uveal
chimeric antigen receptor
adoptive cellular therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924001048
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