Analysis of the influencing factors on serum reversal in HIV-exposed children
Objective To study the factors influencing serum reversal in HIV-exposed children.Methods The general information, clinical data, and serum results of 49 cases of HIV-infected pregnant women and their children exposed to HIV were collected from the Shenzhen Third People's Hospital from January...
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| Format: | Article |
| Language: | zho |
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Editorial Office of New Medicine
2024-05-01
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| Series: | Yixue xinzhi zazhi |
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| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/dgJuqxGKZ5gdldftiMgc4Q8JCkmEDMR31BmiVDcB.pdf |
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| _version_ | 1850102298636713984 |
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| author | LI Xiaoling WU Xiaodong YUAN Dongmei HUANG Ting LIU Xiaoning XIA Junxia LI Shaqian HUANG Haiying HE Yun |
| author_facet | LI Xiaoling WU Xiaodong YUAN Dongmei HUANG Ting LIU Xiaoning XIA Junxia LI Shaqian HUANG Haiying HE Yun |
| author_sort | LI Xiaoling |
| collection | DOAJ |
| description | Objective To study the factors influencing serum reversal in HIV-exposed children.Methods The general information, clinical data, and serum results of 49 cases of HIV-infected pregnant women and their children exposed to HIV were collected from the Shenzhen Third People's Hospital from January 2019 to December 2021.Results All 49 HIV-exposed children were tested negative for HIV nucleic acid at 48 h, 6 weeks, and 3 months of age. The serum reversal rates at 12, 18 and 21 months were 59.18%, 93.87% and 100%, respectively. Whether the serum of HIV-exposed children was reversed at 12 months of age was not related to the maternal delivery, anti-retroviral therapy initiation time, nucleic acid test results, CD4+T lymphocyte count (P>0.05). It was not related to children’s sex, gestational age, birth weight, and the type of blocking drug used (P>0.05).Conclusion No clear influencing factors were found for serum reversal in HIV-exposed 12-month-old children. The consistency between nucleic acid detection and final serum reversal was 100%. In order to exclude the possibility of HIV infection as soon as possible and reduce family concerns, three times of negative nucleic acid results before 3 months of age in HIV-exposed children may be considered as a substitute for serum reversal. |
| format | Article |
| id | doaj-art-50d16c0f87b64898aaa5ee6c3cf8f6ec |
| institution | DOAJ |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2024-05-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-50d16c0f87b64898aaa5ee6c3cf8f6ec2025-08-20T02:39:48ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112024-05-0134551652210.12173/j.issn.1004-5511.2023110876482Analysis of the influencing factors on serum reversal in HIV-exposed childrenLI XiaolingWU XiaodongYUAN DongmeiHUANG TingLIU XiaoningXIA JunxiaLI ShaqianHUANG HaiyingHE YunObjective To study the factors influencing serum reversal in HIV-exposed children.Methods The general information, clinical data, and serum results of 49 cases of HIV-infected pregnant women and their children exposed to HIV were collected from the Shenzhen Third People's Hospital from January 2019 to December 2021.Results All 49 HIV-exposed children were tested negative for HIV nucleic acid at 48 h, 6 weeks, and 3 months of age. The serum reversal rates at 12, 18 and 21 months were 59.18%, 93.87% and 100%, respectively. Whether the serum of HIV-exposed children was reversed at 12 months of age was not related to the maternal delivery, anti-retroviral therapy initiation time, nucleic acid test results, CD4+T lymphocyte count (P>0.05). It was not related to children’s sex, gestational age, birth weight, and the type of blocking drug used (P>0.05).Conclusion No clear influencing factors were found for serum reversal in HIV-exposed 12-month-old children. The consistency between nucleic acid detection and final serum reversal was 100%. In order to exclude the possibility of HIV infection as soon as possible and reduce family concerns, three times of negative nucleic acid results before 3 months of age in HIV-exposed children may be considered as a substitute for serum reversal.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/dgJuqxGKZ5gdldftiMgc4Q8JCkmEDMR31BmiVDcB.pdfhiv-infected pregnant womenhiv-exposed childrenserum reversalearly infant diagnosismother-to-child transmissionnucleic acid testinfluencing factors |
| spellingShingle | LI Xiaoling WU Xiaodong YUAN Dongmei HUANG Ting LIU Xiaoning XIA Junxia LI Shaqian HUANG Haiying HE Yun Analysis of the influencing factors on serum reversal in HIV-exposed children Yixue xinzhi zazhi hiv-infected pregnant women hiv-exposed children serum reversal early infant diagnosis mother-to-child transmission nucleic acid test influencing factors |
| title | Analysis of the influencing factors on serum reversal in HIV-exposed children |
| title_full | Analysis of the influencing factors on serum reversal in HIV-exposed children |
| title_fullStr | Analysis of the influencing factors on serum reversal in HIV-exposed children |
| title_full_unstemmed | Analysis of the influencing factors on serum reversal in HIV-exposed children |
| title_short | Analysis of the influencing factors on serum reversal in HIV-exposed children |
| title_sort | analysis of the influencing factors on serum reversal in hiv exposed children |
| topic | hiv-infected pregnant women hiv-exposed children serum reversal early infant diagnosis mother-to-child transmission nucleic acid test influencing factors |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/dgJuqxGKZ5gdldftiMgc4Q8JCkmEDMR31BmiVDcB.pdf |
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