Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss

Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss

Objectives: Dual incretin agonists are among the most effective pharmaceutical treatments for obesity and type 2 diabetes to date. Such therapeutics can target two receptors, such as the glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor in t...

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Bibliographic Details
Main Authors: Jordan Wean, Allison Ho Kowalsky, Rhianna Laker, Sarah Will, Daniel J. Drucker, Christopher J. Rhodes, Randy J. Seeley
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Molecular Metabolism
Subjects:
Incretin
GLP-1
GIP
Obesity
Anti-obesity medication
Dual-incretin agonism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824002059
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