Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations
BackgroundTo explore the potential association between long-term exposure to raw lacquer and the development of chronic myelomonocytic leukemia (CMML).MethodsWe analyzed the clinical and hematological characteristics of an elderly couple with CMML. Whole-exome sequencing (WES) was performed to ident...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1605369/full |
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| author | Yang Zhang Yujiao Luo Hongling Peng Yafei Yin Guangsen Zhang |
| author_facet | Yang Zhang Yujiao Luo Hongling Peng Yafei Yin Guangsen Zhang |
| author_sort | Yang Zhang |
| collection | DOAJ |
| description | BackgroundTo explore the potential association between long-term exposure to raw lacquer and the development of chronic myelomonocytic leukemia (CMML).MethodsWe analyzed the clinical and hematological characteristics of an elderly couple with CMML. Whole-exome sequencing (WES) was performed to identify relevant gene variants, with a focus on TET2 mutation status.ResultsTwo unrelated CMML patients within the same family, both with over 40 years of raw lacquer exposure, developed CMML. WES revealed that both patients harbored multi-hit TET2 gene mutations and lacked ASXL1 mutations. Both demonstrated relative sensitivity to hydroxyurea or hypomethylating agent (HMA) therapy. Unaffected family members lacked significant raw lacquer exposure.ConclusionsLong-term exposure to raw lacquer may be associated with the onset of familial CMML. CMML patients with multi-hit TET2 mutations in the absence of ASXL1 mutations may have a favorable prognosis. |
| format | Article |
| id | doaj-art-50ccff3cf9ff48c4b7e7a46ba00dc2d9 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-50ccff3cf9ff48c4b7e7a46ba00dc2d92025-08-22T05:26:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.16053691605369Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutationsYang Zhang0Yujiao Luo1Hongling Peng2Yafei Yin3Guangsen Zhang4Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Hematology, Institute of Molecular Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Hematology, Institute of Molecular Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Hematology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, ChinaDepartment of Hematology, Institute of Molecular Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaBackgroundTo explore the potential association between long-term exposure to raw lacquer and the development of chronic myelomonocytic leukemia (CMML).MethodsWe analyzed the clinical and hematological characteristics of an elderly couple with CMML. Whole-exome sequencing (WES) was performed to identify relevant gene variants, with a focus on TET2 mutation status.ResultsTwo unrelated CMML patients within the same family, both with over 40 years of raw lacquer exposure, developed CMML. WES revealed that both patients harbored multi-hit TET2 gene mutations and lacked ASXL1 mutations. Both demonstrated relative sensitivity to hydroxyurea or hypomethylating agent (HMA) therapy. Unaffected family members lacked significant raw lacquer exposure.ConclusionsLong-term exposure to raw lacquer may be associated with the onset of familial CMML. CMML patients with multi-hit TET2 mutations in the absence of ASXL1 mutations may have a favorable prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1605369/fullraw lacquerchronic myelomonocytic leukemiafamilialTET2 mutationRunx1N-ras |
| spellingShingle | Yang Zhang Yujiao Luo Hongling Peng Yafei Yin Guangsen Zhang Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations Frontiers in Oncology raw lacquer chronic myelomonocytic leukemia familial TET2 mutation Runx1 N-ras |
| title | Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations |
| title_full | Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations |
| title_fullStr | Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations |
| title_full_unstemmed | Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations |
| title_short | Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations |
| title_sort | raw lacquer associated familial chronic myelomonocytic leukemia with multi hit tet2 mutations |
| topic | raw lacquer chronic myelomonocytic leukemia familial TET2 mutation Runx1 N-ras |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1605369/full |
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