Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient
IntroductionWe report for the first time a case of a postpubertal patient presenting with a metastatic prepubertal-type testicular teratoma.Case discussionA 29-year-old male with a history of corrected unilateral cryptorchidism presented with progressive bilateral lower extremity edema. Imaging reve...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1547258/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849722933416558592 |
|---|---|
| author | Olivia C. Ghirardelli Smith Alexander K. Tsai Minghao Zhong Pegah Dejban Pegah Dejban Andrew C. Nelson Michelle Dolan Emmanuel S. Antonarakis Paari Murugan |
| author_facet | Olivia C. Ghirardelli Smith Alexander K. Tsai Minghao Zhong Pegah Dejban Pegah Dejban Andrew C. Nelson Michelle Dolan Emmanuel S. Antonarakis Paari Murugan |
| author_sort | Olivia C. Ghirardelli Smith |
| collection | DOAJ |
| description | IntroductionWe report for the first time a case of a postpubertal patient presenting with a metastatic prepubertal-type testicular teratoma.Case discussionA 29-year-old male with a history of corrected unilateral cryptorchidism presented with progressive bilateral lower extremity edema. Imaging revealed an inferior vena cava thrombus associated with a complex mass. A left testicular ultrasound identified a solid lesion suggestive of a germ cell tumor, leading to a left radical orchiectomy, which revealed a mature pure teratoma with no evidence of germ cell neoplasia in situ (GCNIS). Excision of the retroperitoneal mass confirmed the presence of mature teratomatous elements without evidence of non-teratomatous germ cell tumor elements or cytological atypia. Fluorescence in situ hybridization (FISH) showed no evidence of gain of 12p, and next-generation sequencing showed no alterations in genes known to be associated with GCT.ConclusionThis case illustrates that pure mature teratomas lacking chromosome 12p abnormalities, GCNIS, and other dysgenetic features, occurring in postpubertal males, cannot invariably be classified into the benign prepubertal-type teratoma category. Contrary to current paradigm, in rare cases these may represent tumors with metastatic potential. |
| format | Article |
| id | doaj-art-50c876daf6f64146ab4d3882e47a4408 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-50c876daf6f64146ab4d3882e47a44082025-08-20T03:11:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15472581547258Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patientOlivia C. Ghirardelli Smith0Alexander K. Tsai1Minghao Zhong2Pegah Dejban3Pegah Dejban4Andrew C. Nelson5Michelle Dolan6Emmanuel S. Antonarakis7Paari Murugan8Department of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, MN, United StatesDepartment of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, MN, United StatesDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, United StatesDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United StatesDepartment of Medicine, Division of Hematology, Oncology & Transplantation, University of Minnesota, Minneapolis, MN, United StatesDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United StatesIntroductionWe report for the first time a case of a postpubertal patient presenting with a metastatic prepubertal-type testicular teratoma.Case discussionA 29-year-old male with a history of corrected unilateral cryptorchidism presented with progressive bilateral lower extremity edema. Imaging revealed an inferior vena cava thrombus associated with a complex mass. A left testicular ultrasound identified a solid lesion suggestive of a germ cell tumor, leading to a left radical orchiectomy, which revealed a mature pure teratoma with no evidence of germ cell neoplasia in situ (GCNIS). Excision of the retroperitoneal mass confirmed the presence of mature teratomatous elements without evidence of non-teratomatous germ cell tumor elements or cytological atypia. Fluorescence in situ hybridization (FISH) showed no evidence of gain of 12p, and next-generation sequencing showed no alterations in genes known to be associated with GCT.ConclusionThis case illustrates that pure mature teratomas lacking chromosome 12p abnormalities, GCNIS, and other dysgenetic features, occurring in postpubertal males, cannot invariably be classified into the benign prepubertal-type teratoma category. Contrary to current paradigm, in rare cases these may represent tumors with metastatic potential.https://www.frontiersin.org/articles/10.3389/fonc.2025.1547258/fullgerm cell neoplasia in situ (GCNIS)germ cell tumor (GCT)prepubertal-type teratomapostpubertal-type teratomaisochromosome 12p (i12p)testicular cancer |
| spellingShingle | Olivia C. Ghirardelli Smith Alexander K. Tsai Minghao Zhong Pegah Dejban Pegah Dejban Andrew C. Nelson Michelle Dolan Emmanuel S. Antonarakis Paari Murugan Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient Frontiers in Oncology germ cell neoplasia in situ (GCNIS) germ cell tumor (GCT) prepubertal-type teratoma postpubertal-type teratoma isochromosome 12p (i12p) testicular cancer |
| title | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient |
| title_full | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient |
| title_fullStr | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient |
| title_full_unstemmed | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient |
| title_short | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient |
| title_sort | case report prepubertal type testicular teratoma with local metastasis in a postpubertal patient |
| topic | germ cell neoplasia in situ (GCNIS) germ cell tumor (GCT) prepubertal-type teratoma postpubertal-type teratoma isochromosome 12p (i12p) testicular cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1547258/full |
| work_keys_str_mv | AT oliviacghirardellismith casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT alexanderktsai casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT minghaozhong casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT pegahdejban casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT pegahdejban casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT andrewcnelson casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT michelledolan casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT emmanuelsantonarakis casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient AT paarimurugan casereportprepubertaltypetesticularteratomawithlocalmetastasisinapostpubertalpatient |