Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways
Tuberculous meningitis (TBM), a severe form of non-purulent meningitis caused by Mycobacterium tuberculosis (Mtb), is the most critical extrapulmonary tuberculosis (TB) manifestation, with a 30–40% mortality rate despite available treatment. The absence of distinctive clinical symptoms and effective...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1543009/full |
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| author | Fangbo Lin |
| author_facet | Fangbo Lin |
| author_sort | Fangbo Lin |
| collection | DOAJ |
| description | Tuberculous meningitis (TBM), a severe form of non-purulent meningitis caused by Mycobacterium tuberculosis (Mtb), is the most critical extrapulmonary tuberculosis (TB) manifestation, with a 30–40% mortality rate despite available treatment. The absence of distinctive clinical symptoms and effective diagnostic tools complicates early detection. Recent advancements in nucleic acid detection, genomics, metabolomics, and proteomics have led to novel diagnostic approaches, improving sensitivity and specificity. This review focuses on nucleic acid-based methods, including Xpert Ultra, metagenomic next-generation sequencing (mNGS), and single-cell sequencing of whole brain Tissue, alongside the diagnostic potential of metabolomic and proteomic biomarkers. By evaluating the technical features, diagnostic accuracy, and clinical applicability, this review aims to inform the optimization of TBM diagnostic strategies and explores the integration and clinical translation of multi-omics technologies. |
| format | Article |
| id | doaj-art-50c7f4e6f96541c7b54e37ba8853d0fa |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-50c7f4e6f96541c7b54e37ba8853d0fa2025-01-10T05:10:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15430091543009Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathwaysFangbo LinTuberculous meningitis (TBM), a severe form of non-purulent meningitis caused by Mycobacterium tuberculosis (Mtb), is the most critical extrapulmonary tuberculosis (TB) manifestation, with a 30–40% mortality rate despite available treatment. The absence of distinctive clinical symptoms and effective diagnostic tools complicates early detection. Recent advancements in nucleic acid detection, genomics, metabolomics, and proteomics have led to novel diagnostic approaches, improving sensitivity and specificity. This review focuses on nucleic acid-based methods, including Xpert Ultra, metagenomic next-generation sequencing (mNGS), and single-cell sequencing of whole brain Tissue, alongside the diagnostic potential of metabolomic and proteomic biomarkers. By evaluating the technical features, diagnostic accuracy, and clinical applicability, this review aims to inform the optimization of TBM diagnostic strategies and explores the integration and clinical translation of multi-omics technologies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1543009/fulltuberculous meningitishigh-throughputomicssequencingdiagnosistreatment |
| spellingShingle | Fangbo Lin Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways Frontiers in Immunology tuberculous meningitis high-throughput omics sequencing diagnosis treatment |
| title | Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways |
| title_full | Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways |
| title_fullStr | Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways |
| title_full_unstemmed | Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways |
| title_short | Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways |
| title_sort | tuberculous meningitis diagnosis and treatment classic approaches and high throughput pathways |
| topic | tuberculous meningitis high-throughput omics sequencing diagnosis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1543009/full |
| work_keys_str_mv | AT fangbolin tuberculousmeningitisdiagnosisandtreatmentclassicapproachesandhighthroughputpathways |