Ranitidine bismuth citrate: A review
Recognition of the relationship between Helicobacter pylori infection and the development of gastroduodenal disease has increased greatly in recent years. To avoid complications of H pylori infection, such as the development of recurrent duodenal and gastric ulcers, effective therapies are required...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2001/925106 |
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| _version_ | 1832545431371907072 |
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| author | N Chiba RH Hunt ABR Thomson |
| author_facet | N Chiba RH Hunt ABR Thomson |
| author_sort | N Chiba |
| collection | DOAJ |
| description | Recognition of the relationship between Helicobacter pylori infection and the development of gastroduodenal disease has increased greatly in recent years. To avoid complications of H pylori infection, such as the development of recurrent duodenal and gastric ulcers, effective therapies are required for eradication of the infection. This article reviews ranitidine bismuth citrate (RBC), a novel complex of ranitidine, bismuth and citrate, which was developed specifically for the purpose of eradicating H pylori. Dual therapy with RBC in combination with clarithromycin for 14 days yields eradication rates of 76%. Triple therapy bid for one week with a proton pump inhibitor, clarithromycin and either amoxicillin or a nitroimidazole (tinidazole or metronidazole) is advocated as the treatment of choice for H pylori eradication. Analogous regimens with RBC in place of proton pump inhibitors show effective eradication rates in comparative studies and with pooled data. RBC, used alone or in combination with other antibiotics, appears to be a safe and effective drug for the treatment of H pylori infection. Bismuth levels do not appear to rise to toxic levels. |
| format | Article |
| id | doaj-art-50c59b10f64f42abb8883de25eb0dfd8 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-50c59b10f64f42abb8883de25eb0dfd82025-02-03T07:25:43ZengWileyCanadian Journal of Gastroenterology0835-79002001-01-0115638939810.1155/2001/925106Ranitidine bismuth citrate: A reviewN Chiba0RH Hunt1ABR Thomson2Surrey GI Clinic/Research, Guelph, Ontario, CanadaDepartment of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, CanadaDepartment of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaRecognition of the relationship between Helicobacter pylori infection and the development of gastroduodenal disease has increased greatly in recent years. To avoid complications of H pylori infection, such as the development of recurrent duodenal and gastric ulcers, effective therapies are required for eradication of the infection. This article reviews ranitidine bismuth citrate (RBC), a novel complex of ranitidine, bismuth and citrate, which was developed specifically for the purpose of eradicating H pylori. Dual therapy with RBC in combination with clarithromycin for 14 days yields eradication rates of 76%. Triple therapy bid for one week with a proton pump inhibitor, clarithromycin and either amoxicillin or a nitroimidazole (tinidazole or metronidazole) is advocated as the treatment of choice for H pylori eradication. Analogous regimens with RBC in place of proton pump inhibitors show effective eradication rates in comparative studies and with pooled data. RBC, used alone or in combination with other antibiotics, appears to be a safe and effective drug for the treatment of H pylori infection. Bismuth levels do not appear to rise to toxic levels.http://dx.doi.org/10.1155/2001/925106 |
| spellingShingle | N Chiba RH Hunt ABR Thomson Ranitidine bismuth citrate: A review Canadian Journal of Gastroenterology |
| title | Ranitidine bismuth citrate: A review |
| title_full | Ranitidine bismuth citrate: A review |
| title_fullStr | Ranitidine bismuth citrate: A review |
| title_full_unstemmed | Ranitidine bismuth citrate: A review |
| title_short | Ranitidine bismuth citrate: A review |
| title_sort | ranitidine bismuth citrate a review |
| url | http://dx.doi.org/10.1155/2001/925106 |
| work_keys_str_mv | AT nchiba ranitidinebismuthcitrateareview AT rhhunt ranitidinebismuthcitrateareview AT abrthomson ranitidinebismuthcitrateareview |