9-cis-Retinoic Acid Improves Disease Modelling in iPSC-Derived Liver Organoids

9-cis-Retinoic Acid Improves Disease Modelling in iPSC-Derived Liver Organoids

Liver fibrosis majorly impacts global health, necessitating the development of in vitro models to study disease mechanisms and develop drug therapies. Relevant models should at least include hepatocytes and hepatic stellate cells (HSCs) and ideally use three-dimensional cultures to mimic in vivo con...

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Bibliographic Details
Main Authors: Mina Kazemzadeh Dastjerd, Vincent Merens, Ayla Smout, Rebeca De Wolf, Christophe Chesné, Catherine Verfaillie, Stefaan Verhulst, Leo A. van Grunsven
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
liver fibrosis
DILI
hepatic stellate cell activation
hepatocytes
drug metabolism
iPSC
Online Access:https://www.mdpi.com/2073-4409/14/13/983
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