Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients
Purpose. To determine if recent preoperative exposure to n-acetylcysteine (NAC), Mucomyst, increases postoperative blood loss in cardiac surgery patients. Methods. Retrospective review of cardiac surgery patients who underwent a cardiac catheterization within four days of surgery and whose serum cre...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/859020 |
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| author | Amber R. Wesner Marcia L. Brackbill Christine S. Sytsma |
| author_facet | Amber R. Wesner Marcia L. Brackbill Christine S. Sytsma |
| author_sort | Amber R. Wesner |
| collection | DOAJ |
| description | Purpose. To determine if recent preoperative exposure to n-acetylcysteine (NAC), Mucomyst, increases postoperative blood loss in cardiac surgery patients. Methods. Retrospective review of cardiac surgery patients who underwent a cardiac catheterization within four days of surgery and whose serum creatinine was ≥1.0 mg/dL. The study groups were those who received NAC in the pericatheterization period versus those who did not. The primary endpoint was postoperative chest tube output at 24, 48, and 72 hours. Secondary endpoints included number of transfusions and other bleeding parameters. Results. Mean blood loss in the first 24 hours was 962 ± 595 mL in the treatment group (n=79) and 1,178 ± 788 mL in the control group (n=106), P=.040. Blood loss between groups at 48 (366 ± 318 mL versus 412 ± 363 mL, P=.382) and 72 (194 ± 300 mL versus 176 ± 224 mL, P=.643) hours was not significantly different. There were no significant differences in postoperative transfusions or other bleeding parameters. Conclusions. Preoperative exposure to NAC did not increase postoperative blood loss or negatively affect other bleeding parameters. |
| format | Article |
| id | doaj-art-50bebd9873a342748736d050351fbfeb |
| institution | OA Journals |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-50bebd9873a342748736d050351fbfeb2025-08-20T02:05:17ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322011-01-01201110.1155/2011/859020859020Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery PatientsAmber R. Wesner0Marcia L. Brackbill1Christine S. Sytsma2Pharmacy Department, Winchester Medical Center, 1840 Amherst Street, Winchester, VA 22601, USAPharmacy Department, Winchester Medical Center, 1840 Amherst Street, Winchester, VA 22601, USAPharmacy Department, Winchester Medical Center, 1840 Amherst Street, Winchester, VA 22601, USAPurpose. To determine if recent preoperative exposure to n-acetylcysteine (NAC), Mucomyst, increases postoperative blood loss in cardiac surgery patients. Methods. Retrospective review of cardiac surgery patients who underwent a cardiac catheterization within four days of surgery and whose serum creatinine was ≥1.0 mg/dL. The study groups were those who received NAC in the pericatheterization period versus those who did not. The primary endpoint was postoperative chest tube output at 24, 48, and 72 hours. Secondary endpoints included number of transfusions and other bleeding parameters. Results. Mean blood loss in the first 24 hours was 962 ± 595 mL in the treatment group (n=79) and 1,178 ± 788 mL in the control group (n=106), P=.040. Blood loss between groups at 48 (366 ± 318 mL versus 412 ± 363 mL, P=.382) and 72 (194 ± 300 mL versus 176 ± 224 mL, P=.643) hours was not significantly different. There were no significant differences in postoperative transfusions or other bleeding parameters. Conclusions. Preoperative exposure to NAC did not increase postoperative blood loss or negatively affect other bleeding parameters.http://dx.doi.org/10.1155/2011/859020 |
| spellingShingle | Amber R. Wesner Marcia L. Brackbill Christine S. Sytsma Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients International Journal of Vascular Medicine |
| title | Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients |
| title_full | Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients |
| title_fullStr | Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients |
| title_full_unstemmed | Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients |
| title_short | Effect of Preoperative N-Acetylcysteine on Postoperative Blood Loss Parameters in Cardiac Surgery Patients |
| title_sort | effect of preoperative n acetylcysteine on postoperative blood loss parameters in cardiac surgery patients |
| url | http://dx.doi.org/10.1155/2011/859020 |
| work_keys_str_mv | AT amberrwesner effectofpreoperativenacetylcysteineonpostoperativebloodlossparametersincardiacsurgerypatients AT marcialbrackbill effectofpreoperativenacetylcysteineonpostoperativebloodlossparametersincardiacsurgerypatients AT christinessytsma effectofpreoperativenacetylcysteineonpostoperativebloodlossparametersincardiacsurgerypatients |