The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities
Abstract Cellular senescence is characterized by a stable cell cycle arrest and a hypersecretory, proinflammatory phenotype in response to various stress stimuli. Traditionally, this state has been viewed as a tumor‐suppressing mechanism that prevents the proliferation of damaged cells while activat...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.70048 |
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| _version_ | 1832594208520667136 |
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| author | Zehua Wang Chen Chen Jiaoyu Ai Yaping Gao Lei Wang Shurui Xia Yongxu Jia Yanru Qin |
| author_facet | Zehua Wang Chen Chen Jiaoyu Ai Yaping Gao Lei Wang Shurui Xia Yongxu Jia Yanru Qin |
| author_sort | Zehua Wang |
| collection | DOAJ |
| description | Abstract Cellular senescence is characterized by a stable cell cycle arrest and a hypersecretory, proinflammatory phenotype in response to various stress stimuli. Traditionally, this state has been viewed as a tumor‐suppressing mechanism that prevents the proliferation of damaged cells while activating the immune response for their clearance. However, senescence is increasingly recognized as a contributing factor to tumor progression. This dual role necessitates a careful evaluation of the beneficial and detrimental aspects of senescence within the tumor microenvironment (TME). Specifically, senescent cells display a unique senescence‐associated secretory phenotype that releases a diverse array of soluble factors affecting the TME. Furthermore, the impact of senescence on tumor–immune interaction is complex and often underappreciated. Senescent immune cells create an immunosuppressive TME favoring tumor progression. In contrast, senescent tumor cells could promote a transition from immune evasion to clearance. Given these intricate dynamics, therapies targeting senescence hold promise for advancing antitumor strategies. This review aims to summarize the dual effects of senescence on tumor progression, explore its influence on tumor–immune interactions, and discuss potential therapeutic strategies, alongside challenges and future directions. Understanding how senescence regulates antitumor immunity, along with new therapeutic interventions, is essential for managing tumor cell senescence and remodeling the immune microenvironment. |
| format | Article |
| id | doaj-art-50be7a7f12dc41abb359fdab0975adca |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-50be7a7f12dc41abb359fdab0975adca2025-01-20T01:45:44ZengWileyMedComm2688-26632025-01-0161n/an/a10.1002/mco2.70048The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunitiesZehua Wang0Chen Chen1Jiaoyu Ai2Yaping Gao3Lei Wang4Shurui Xia5Yongxu Jia6Yanru Qin7Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanchang UniversityNanchang ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaAbstract Cellular senescence is characterized by a stable cell cycle arrest and a hypersecretory, proinflammatory phenotype in response to various stress stimuli. Traditionally, this state has been viewed as a tumor‐suppressing mechanism that prevents the proliferation of damaged cells while activating the immune response for their clearance. However, senescence is increasingly recognized as a contributing factor to tumor progression. This dual role necessitates a careful evaluation of the beneficial and detrimental aspects of senescence within the tumor microenvironment (TME). Specifically, senescent cells display a unique senescence‐associated secretory phenotype that releases a diverse array of soluble factors affecting the TME. Furthermore, the impact of senescence on tumor–immune interaction is complex and often underappreciated. Senescent immune cells create an immunosuppressive TME favoring tumor progression. In contrast, senescent tumor cells could promote a transition from immune evasion to clearance. Given these intricate dynamics, therapies targeting senescence hold promise for advancing antitumor strategies. This review aims to summarize the dual effects of senescence on tumor progression, explore its influence on tumor–immune interactions, and discuss potential therapeutic strategies, alongside challenges and future directions. Understanding how senescence regulates antitumor immunity, along with new therapeutic interventions, is essential for managing tumor cell senescence and remodeling the immune microenvironment.https://doi.org/10.1002/mco2.70048cancer treatmentcellular senescenceimmunitySASPtumor microenvironmenttumor progression |
| spellingShingle | Zehua Wang Chen Chen Jiaoyu Ai Yaping Gao Lei Wang Shurui Xia Yongxu Jia Yanru Qin The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities MedComm cancer treatment cellular senescence immunity SASP tumor microenvironment tumor progression |
| title | The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities |
| title_full | The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities |
| title_fullStr | The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities |
| title_full_unstemmed | The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities |
| title_short | The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities |
| title_sort | crosstalk between senescence tumor and immunity molecular mechanism and therapeutic opportunities |
| topic | cancer treatment cellular senescence immunity SASP tumor microenvironment tumor progression |
| url | https://doi.org/10.1002/mco2.70048 |
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