Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments
Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. So, in recent years, researchers and surgeons have been working hard to elaborate cartilage rep...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/438026 |
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| _version_ | 1849406777512165376 |
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| author | Catherine Baugé Karim Boumédiene |
| author_facet | Catherine Baugé Karim Boumédiene |
| author_sort | Catherine Baugé |
| collection | DOAJ |
| description | Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. So, in recent years, researchers and surgeons have been working hard to elaborate cartilage repair interventions for patients who suffer from cartilage damage. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or hypertrophic cartilage. In the next years, the development of new strategies using adult stem cells, in scaffolds, with supplementation of culture medium and/or culture in low oxygen tension should improve the quality of neoformed cartilage. Through these solutions, some of the latest technologies start to bring very promising results in repairing cartilage from traumatic injury or chondropathies. This review discusses the current knowledge about the use of adult stem cells in the context of cartilage tissue engineering and presents clinical trials in progress, as well as in the future, especially in the field of bioprinting stem cells. |
| format | Article |
| id | doaj-art-50b916f4d7ee400a9899b026fd0b4b66 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-50b916f4d7ee400a9899b026fd0b4b662025-08-20T03:36:15ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/438026438026Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future DevelopmentsCatherine Baugé0Karim Boumédiene1Normandie Université, 14032 Caen, FranceNormandie Université, 14032 Caen, FranceDue to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. So, in recent years, researchers and surgeons have been working hard to elaborate cartilage repair interventions for patients who suffer from cartilage damage. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or hypertrophic cartilage. In the next years, the development of new strategies using adult stem cells, in scaffolds, with supplementation of culture medium and/or culture in low oxygen tension should improve the quality of neoformed cartilage. Through these solutions, some of the latest technologies start to bring very promising results in repairing cartilage from traumatic injury or chondropathies. This review discusses the current knowledge about the use of adult stem cells in the context of cartilage tissue engineering and presents clinical trials in progress, as well as in the future, especially in the field of bioprinting stem cells.http://dx.doi.org/10.1155/2015/438026 |
| spellingShingle | Catherine Baugé Karim Boumédiene Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments Stem Cells International |
| title | Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments |
| title_full | Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments |
| title_fullStr | Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments |
| title_full_unstemmed | Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments |
| title_short | Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments |
| title_sort | use of adult stem cells for cartilage tissue engineering current status and future developments |
| url | http://dx.doi.org/10.1155/2015/438026 |
| work_keys_str_mv | AT catherinebauge useofadultstemcellsforcartilagetissueengineeringcurrentstatusandfuturedevelopments AT karimboumediene useofadultstemcellsforcartilagetissueengineeringcurrentstatusandfuturedevelopments |