Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China
ObjectiveTo investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.MethodsThis multicenter, cross-sectional study included 21,811 children aged 0–18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method fr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | International Journal of Public Health |
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| Online Access: | https://www.ssph-journal.org/articles/10.3389/ijph.2024.1607411/full |
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| author | Chuican Huang Sijia Liu Chen Cheng Shiyun Chen Qing Luo Yan Huang Yanxian Yao Xixia Ye Haizhen Wang Liangyi Luo Junwei Xie Hongai Li Yumei Duan Beibei Liu Wenting Cao Fangfang Zeng Wei Xiang Lichun Fan |
| author_facet | Chuican Huang Sijia Liu Chen Cheng Shiyun Chen Qing Luo Yan Huang Yanxian Yao Xixia Ye Haizhen Wang Liangyi Luo Junwei Xie Hongai Li Yumei Duan Beibei Liu Wenting Cao Fangfang Zeng Wei Xiang Lichun Fan |
| author_sort | Chuican Huang |
| collection | DOAJ |
| description | ObjectiveTo investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.MethodsThis multicenter, cross-sectional study included 21,811 children aged 0–18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method from January 2021 to March 2022.ResultsSerum 25(OH)D levels decreased with age (p trend <0.001). VDD prevalence increased significantly from 3.7% (95% CI: 3.2, 4.3) in children aged 0–3 years to 43.5% (95% CI: 42.1, 45.0) in those aged 13–18 years. Girls and urban residents showed higher deficiency rates. Adolescents (13–18 years) had the highest prevalence of VDD (43.5%), while toddlers (0–3 years) had the lowest (3.7%). Factors influencing vitamin D status included gender, urban residency, and breastfeeding duration. Seasonal variations showed higher deficiency rates in autumn, particularly among preschoolers. Regional differences were noted, with the highest deficiency in semiarid and subhumid zones for various age groups.ConclusionA significant increase in VDD with age, particularly among adolescents, urban girls, and during autumn, emphasizing the need for targeted strategies. |
| format | Article |
| id | doaj-art-50b889318c9c43f7ac99305c86b42b54 |
| institution | Kabale University |
| issn | 1661-8564 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | International Journal of Public Health |
| spelling | doaj-art-50b889318c9c43f7ac99305c86b42b542025-01-06T04:12:11ZengFrontiers Media S.A.International Journal of Public Health1661-85642025-01-016910.3389/ijph.2024.16074111607411Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern ChinaChuican Huang0Sijia Liu1Chen Cheng2Shiyun Chen3Qing Luo4Yan Huang5Yanxian Yao6Xixia Ye7Haizhen Wang8Liangyi Luo9Junwei Xie10Hongai Li11Yumei Duan12Beibei Liu13Wenting Cao14Fangfang Zeng15Wei Xiang16Lichun Fan17Department of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaDepartment of Epidemiology, International School of Public Health and One Health, Hainan Medical University, Haikou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaNational Health Commission (NHC) Key Laboratory of Control of Tropical Diseases, Hainan Medical University, Haikou, ChinaDepartment of Child Healthcare, Hainan Women and Children’s Medical Center (Children’s Hospital Affiliated to Hainan Medical University), Haikou, ChinaObjectiveTo investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.MethodsThis multicenter, cross-sectional study included 21,811 children aged 0–18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method from January 2021 to March 2022.ResultsSerum 25(OH)D levels decreased with age (p trend <0.001). VDD prevalence increased significantly from 3.7% (95% CI: 3.2, 4.3) in children aged 0–3 years to 43.5% (95% CI: 42.1, 45.0) in those aged 13–18 years. Girls and urban residents showed higher deficiency rates. Adolescents (13–18 years) had the highest prevalence of VDD (43.5%), while toddlers (0–3 years) had the lowest (3.7%). Factors influencing vitamin D status included gender, urban residency, and breastfeeding duration. Seasonal variations showed higher deficiency rates in autumn, particularly among preschoolers. Regional differences were noted, with the highest deficiency in semiarid and subhumid zones for various age groups.ConclusionA significant increase in VDD with age, particularly among adolescents, urban girls, and during autumn, emphasizing the need for targeted strategies.https://www.ssph-journal.org/articles/10.3389/ijph.2024.1607411/fullchildrenvitamin D deficiencyrisk factorscross-sectional studySouthern China |
| spellingShingle | Chuican Huang Sijia Liu Chen Cheng Shiyun Chen Qing Luo Yan Huang Yanxian Yao Xixia Ye Haizhen Wang Liangyi Luo Junwei Xie Hongai Li Yumei Duan Beibei Liu Wenting Cao Fangfang Zeng Wei Xiang Lichun Fan Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China International Journal of Public Health children vitamin D deficiency risk factors cross-sectional study Southern China |
| title | Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China |
| title_full | Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China |
| title_fullStr | Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China |
| title_full_unstemmed | Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China |
| title_short | Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China |
| title_sort | vitamin d deficiency and associated factors in children a multicenter study of 21 811 samples in southern china |
| topic | children vitamin D deficiency risk factors cross-sectional study Southern China |
| url | https://www.ssph-journal.org/articles/10.3389/ijph.2024.1607411/full |
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