The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking
IntroductionPhthalates (PAEs) are widely used plasticizers in polyvinyl chloride (PVC) products since the 1930s, and recent research indicates a significant association between exposure to these substances and the development and progression of asthma and chronic obstructive pulmonary disease (COPD)...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1566965/full |
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| author | Ren Li Ren Li Ren Li Bingqing Zheng Bingqing Zheng Bingqing Zheng Yuqiong Zhang Yuqiong Zhang Yuqiong Zhang Lu He Chaomin Ren Chaomin Ren Chaomin Ren Linlin Guan Linlin Guan Linlin Guan Huan Yang Huan Yang Huan Yang Jiayu Tian Jiayu Tian Jiayu Tian Xingyi Chen Xingyi Chen Xingyi Chen Dongxing Shi Dongxing Shi Dongxing Shi Lifang Zhao Lifang Zhao Lifang Zhao Zhihong Zhang Zhihong Zhang Zhihong Zhang |
| author_facet | Ren Li Ren Li Ren Li Bingqing Zheng Bingqing Zheng Bingqing Zheng Yuqiong Zhang Yuqiong Zhang Yuqiong Zhang Lu He Chaomin Ren Chaomin Ren Chaomin Ren Linlin Guan Linlin Guan Linlin Guan Huan Yang Huan Yang Huan Yang Jiayu Tian Jiayu Tian Jiayu Tian Xingyi Chen Xingyi Chen Xingyi Chen Dongxing Shi Dongxing Shi Dongxing Shi Lifang Zhao Lifang Zhao Lifang Zhao Zhihong Zhang Zhihong Zhang Zhihong Zhang |
| author_sort | Ren Li |
| collection | DOAJ |
| description | IntroductionPhthalates (PAEs) are widely used plasticizers in polyvinyl chloride (PVC) products since the 1930s, and recent research indicates a significant association between exposure to these substances and the development and progression of asthma and chronic obstructive pulmonary disease (COPD). Understanding the underlying mechanisms is crucial due to their public health implications.MethodsIn this study, we utilized innovative network toxicology and molecular docking techniques to systematically examine the effects of seven typical phthalates on asthma and COPD. By integrating information from multiple databases, we identified key target genes linked to these compounds and conducted functional enrichment analyses to elucidate their roles in pathological processes.ResultsOur results demonstrate that these phthalates affect the pathogenesis of asthma and COPD by modulating various target genes, including PTGS2, MMP9, and CASP3, which are involved in essential biological pathways such as apoptosis and immune response. Interestingly, certain inflammation-related genes and signaling pathways displayed novel regulatory patterns when exposed to phthalates, revealing new pathological mechanisms. Molecular docking analyses further confirmed stable interactions between phthalates and essential target genes, providing molecular-level insights into their pathogenic mechanisms.DiscussionOverall, this study highlights the harmful impacts of these seven phthalates on asthma and COPD, establishing new connections between the compounds and disease-related genes, and emphasizing their relevance as emerging environmental toxins. These findings provide valuable perspectives for risk assessment and public health policy, underscoring the need for stricter regulations and interventions regarding phthalate exposure. |
| format | Article |
| id | doaj-art-50b31b04ee2b4596bb8ca4180de2044a |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-50b31b04ee2b4596bb8ca4180de2044a2025-08-20T02:56:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15669651566965The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular dockingRen Li0Ren Li1Ren Li2Bingqing Zheng3Bingqing Zheng4Bingqing Zheng5Yuqiong Zhang6Yuqiong Zhang7Yuqiong Zhang8Lu He9Chaomin Ren10Chaomin Ren11Chaomin Ren12Linlin Guan13Linlin Guan14Linlin Guan15Huan Yang16Huan Yang17Huan Yang18Jiayu Tian19Jiayu Tian20Jiayu Tian21Xingyi Chen22Xingyi Chen23Xingyi Chen24Dongxing Shi25Dongxing Shi26Dongxing Shi27Lifang Zhao28Lifang Zhao29Lifang Zhao30Zhihong Zhang31Zhihong Zhang32Zhihong Zhang33Department of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Public Health Laboratory Sciences, School of Public Health, Shanxi Medical University, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaDepartment of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, ChinaCenter for Ecological Public Health Security of Yellow River Basin, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan, ChinaIntroductionPhthalates (PAEs) are widely used plasticizers in polyvinyl chloride (PVC) products since the 1930s, and recent research indicates a significant association between exposure to these substances and the development and progression of asthma and chronic obstructive pulmonary disease (COPD). Understanding the underlying mechanisms is crucial due to their public health implications.MethodsIn this study, we utilized innovative network toxicology and molecular docking techniques to systematically examine the effects of seven typical phthalates on asthma and COPD. By integrating information from multiple databases, we identified key target genes linked to these compounds and conducted functional enrichment analyses to elucidate their roles in pathological processes.ResultsOur results demonstrate that these phthalates affect the pathogenesis of asthma and COPD by modulating various target genes, including PTGS2, MMP9, and CASP3, which are involved in essential biological pathways such as apoptosis and immune response. Interestingly, certain inflammation-related genes and signaling pathways displayed novel regulatory patterns when exposed to phthalates, revealing new pathological mechanisms. Molecular docking analyses further confirmed stable interactions between phthalates and essential target genes, providing molecular-level insights into their pathogenic mechanisms.DiscussionOverall, this study highlights the harmful impacts of these seven phthalates on asthma and COPD, establishing new connections between the compounds and disease-related genes, and emphasizing their relevance as emerging environmental toxins. These findings provide valuable perspectives for risk assessment and public health policy, underscoring the need for stricter regulations and interventions regarding phthalate exposure.https://www.frontiersin.org/articles/10.3389/fphar.2025.1566965/fullphthalatesasthmaCOPDnetwork toxicologymolecular docking |
| spellingShingle | Ren Li Ren Li Ren Li Bingqing Zheng Bingqing Zheng Bingqing Zheng Yuqiong Zhang Yuqiong Zhang Yuqiong Zhang Lu He Chaomin Ren Chaomin Ren Chaomin Ren Linlin Guan Linlin Guan Linlin Guan Huan Yang Huan Yang Huan Yang Jiayu Tian Jiayu Tian Jiayu Tian Xingyi Chen Xingyi Chen Xingyi Chen Dongxing Shi Dongxing Shi Dongxing Shi Lifang Zhao Lifang Zhao Lifang Zhao Zhihong Zhang Zhihong Zhang Zhihong Zhang The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking Frontiers in Pharmacology phthalates asthma COPD network toxicology molecular docking |
| title | The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking |
| title_full | The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking |
| title_fullStr | The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking |
| title_full_unstemmed | The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking |
| title_short | The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking |
| title_sort | impact of phthalates on asthma and chronic obstructive pulmonary disease a comprehensive analysis based on network toxicology and molecular docking |
| topic | phthalates asthma COPD network toxicology molecular docking |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1566965/full |
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