Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD
Study Objectives. Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) commonly cooccur. Approaches to research and treatment of these disorders have been segregated, despite overlapping symptomology. We and others have hypothesized that comorbid TBI + PTSD generates worse symptoms...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/6037015 |
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| _version_ | 1850224024601231360 |
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| author | Peyton Teutsch Carolyn E. Jones Mara E. Kaiser Natasha Avalon Gardner Miranda M. Lim |
| author_facet | Peyton Teutsch Carolyn E. Jones Mara E. Kaiser Natasha Avalon Gardner Miranda M. Lim |
| author_sort | Peyton Teutsch |
| collection | DOAJ |
| description | Study Objectives. Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) commonly cooccur. Approaches to research and treatment of these disorders have been segregated, despite overlapping symptomology. We and others have hypothesized that comorbid TBI + PTSD generates worse symptoms than either condition alone. We present a mouse model of comorbid TBI + PTSD to further explore this condition. Methods. A mouse model of TBI + PTSD was generated using the single prolonged stress (SPS) protocol in combination with the controlled cortical impact (CCI) protocol. This resulted in four experimental groups: control, TBI, PTSD, and TBI + PTSD. Behavioral phenotyping included gait analysis, contextual fear conditioning, acoustic startle response, and prepulse inhibition. Results. Mice in the TBI + PTSD group showed a significantly impaired gait compared to their counterparts with TBI alone as well as control mice. Mice in the TBI + PTSD group showed significantly impaired contextual fear recall compared to controls. Prepulse inhibition testing revealed intact acoustic startle and auditory sensory gating. Conclusions. These results indicate that SPS paired with CCI in mice produces unique behavioral impairments in gait and fear recall that are not present in either condition alone. Further studies are underway to examine additional behavioral, physiological, and pathological phenotypes in this combined model of TBI + PTSD. |
| format | Article |
| id | doaj-art-50b1ddf59ce543b5bd2de171a8fbc77f |
| institution | OA Journals |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-50b1ddf59ce543b5bd2de171a8fbc77f2025-08-20T02:05:45ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/60370156037015Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSDPeyton Teutsch0Carolyn E. Jones1Mara E. Kaiser2Natasha Avalon Gardner3Miranda M. Lim4VA Portland Health Care System, Portland, OR, USAVA Portland Health Care System, Portland, OR, USAVA Portland Health Care System, Portland, OR, USAVA Portland Health Care System, Portland, OR, USAVA Portland Health Care System, Portland, OR, USAStudy Objectives. Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) commonly cooccur. Approaches to research and treatment of these disorders have been segregated, despite overlapping symptomology. We and others have hypothesized that comorbid TBI + PTSD generates worse symptoms than either condition alone. We present a mouse model of comorbid TBI + PTSD to further explore this condition. Methods. A mouse model of TBI + PTSD was generated using the single prolonged stress (SPS) protocol in combination with the controlled cortical impact (CCI) protocol. This resulted in four experimental groups: control, TBI, PTSD, and TBI + PTSD. Behavioral phenotyping included gait analysis, contextual fear conditioning, acoustic startle response, and prepulse inhibition. Results. Mice in the TBI + PTSD group showed a significantly impaired gait compared to their counterparts with TBI alone as well as control mice. Mice in the TBI + PTSD group showed significantly impaired contextual fear recall compared to controls. Prepulse inhibition testing revealed intact acoustic startle and auditory sensory gating. Conclusions. These results indicate that SPS paired with CCI in mice produces unique behavioral impairments in gait and fear recall that are not present in either condition alone. Further studies are underway to examine additional behavioral, physiological, and pathological phenotypes in this combined model of TBI + PTSD.http://dx.doi.org/10.1155/2018/6037015 |
| spellingShingle | Peyton Teutsch Carolyn E. Jones Mara E. Kaiser Natasha Avalon Gardner Miranda M. Lim Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD Behavioural Neurology |
| title | Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD |
| title_full | Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD |
| title_fullStr | Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD |
| title_full_unstemmed | Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD |
| title_short | Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD |
| title_sort | gait and conditioned fear impairments in a mouse model of comorbid tbi and ptsd |
| url | http://dx.doi.org/10.1155/2018/6037015 |
| work_keys_str_mv | AT peytonteutsch gaitandconditionedfearimpairmentsinamousemodelofcomorbidtbiandptsd AT carolynejones gaitandconditionedfearimpairmentsinamousemodelofcomorbidtbiandptsd AT maraekaiser gaitandconditionedfearimpairmentsinamousemodelofcomorbidtbiandptsd AT natashaavalongardner gaitandconditionedfearimpairmentsinamousemodelofcomorbidtbiandptsd AT mirandamlim gaitandconditionedfearimpairmentsinamousemodelofcomorbidtbiandptsd |