Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review
The cadherin superfamily of proteins is critical for cell-cell interactions and demonstrates tissue-specific expression profiles. In cancers, disruption of cell-cell adhesion is frequently associated with oncogenesis and metastasis. As such, these proteins have been the targets of multiple attempts...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Innovative Healthcare Institute
2025-01-01
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| Series: | Journal of Immunotherapy and Precision Oncology |
| Subjects: | |
| Online Access: | https://jipo.org/doi/pdf/10.36401/JIPO-24-20 |
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| _version_ | 1850079581752524800 |
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| author | Jacob Keeling Gerald Falchook |
| author_facet | Jacob Keeling Gerald Falchook |
| author_sort | Jacob Keeling |
| collection | DOAJ |
| description | The cadherin superfamily of proteins is critical for cell-cell interactions and demonstrates tissue-specific expression profiles. In cancers, disruption of cell-cell adhesion is frequently associated with oncogenesis and metastasis. As such, these proteins have been the targets of multiple attempts to develop novel therapeutics in malignancy. This review article discusses prior and current clinical trials targeting the cadherin proteins. |
| format | Article |
| id | doaj-art-50a97fef3fc84528b794a3c18f3309d0 |
| institution | DOAJ |
| issn | 2666-2345 2590-017X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Innovative Healthcare Institute |
| record_format | Article |
| series | Journal of Immunotherapy and Precision Oncology |
| spelling | doaj-art-50a97fef3fc84528b794a3c18f3309d02025-08-20T02:45:10ZengInnovative Healthcare InstituteJournal of Immunotherapy and Precision Oncology2666-23452590-017X2025-01-0181233310.36401/JIPO-24-20i2590-017X-8-1-23Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A ReviewJacob Keeling0Gerald Falchook11 Sky Ridge Internal Medicine Residency Program, Lone Tree, CO, USA2 Sarah Cannon Research Institute (SCRI) at HealthONE, Denver, CO, USAThe cadherin superfamily of proteins is critical for cell-cell interactions and demonstrates tissue-specific expression profiles. In cancers, disruption of cell-cell adhesion is frequently associated with oncogenesis and metastasis. As such, these proteins have been the targets of multiple attempts to develop novel therapeutics in malignancy. This review article discusses prior and current clinical trials targeting the cadherin proteins.https://jipo.org/doi/pdf/10.36401/JIPO-24-20cadherinsclinical trialscancercdh6 |
| spellingShingle | Jacob Keeling Gerald Falchook Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review Journal of Immunotherapy and Precision Oncology cadherins clinical trials cancer cdh6 |
| title | Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review |
| title_full | Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review |
| title_fullStr | Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review |
| title_full_unstemmed | Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review |
| title_short | Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review |
| title_sort | oncology clinical trials targeting members of the cadherin superfamily a review |
| topic | cadherins clinical trials cancer cdh6 |
| url | https://jipo.org/doi/pdf/10.36401/JIPO-24-20 |
| work_keys_str_mv | AT jacobkeeling oncologyclinicaltrialstargetingmembersofthecadherinsuperfamilyareview AT geraldfalchook oncologyclinicaltrialstargetingmembersofthecadherinsuperfamilyareview |