Identification of cellular senescence-related genes as biomarkers for lupus nephritis based on bioinformatics

Identification of cellular senescence-related genes as biomarkers for lupus nephritis based on bioinformatics

BackgroundLupus nephritis (LN) is one of the most common and severe complications of systemic lupus erythematosus with unclear pathogenesis. The most accurate diagnosis criterion of LN is still renal biopsy and nowadays treatment strategies of LN are far from satisfactory. Cellular senescence is def...

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Bibliographic Details
Main Authors: Wei Chen, Xiaofang Wang, Guoshun Huang, Qin Sheng, Enchao Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Genetics
Subjects:
lupus nephritis
cellular senescence
biomarker
weighted gene Co-expression network (WGCNA)
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1551450/full
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