Molecular model of TFIIH recruitment to the transcription-coupled repair machinery

Abstract Transcription-coupled repair (TCR) is a vital nucleotide excision repair sub-pathway that removes DNA lesions from actively transcribed DNA strands. Binding of CSB to lesion-stalled RNA Polymerase II (Pol II) initiates TCR by triggering the recruitment of downstream repair factors. Yet it r...

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Bibliographic Details
Main Authors: Tanmoy Paul, Chunli Yan, Jina Yu, Susan E. Tsutakawa, John A. Tainer, Dong Wang, Ivaylo Ivanov
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57593-0
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