HIF1A overexpression promotes osteoblast differentiation through activation of autophagy to alleviate osteoporosis

HIF1A overexpression promotes osteoblast differentiation through activation of autophagy to alleviate osteoporosis

Abstract Objective Osteoporosis (OP) is a systemic skeletal disease that increases the risk of fractures by weaking bone. Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in osteogenesis and osteoblastic differentiation. The purpose of this study is to examine the underlying mechanism of HI...

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Bibliographic Details
Main Authors: Jiutao Qiao, Aiyun Liu, Chongyi Sun, Qingpeng Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Osteoporosis
HIF-1a
Autophagy
Osteogenic differentiation
Bone metabolism
Online Access:https://doi.org/10.1038/s41598-025-16046-w
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