PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications
PANoptosis has been shown to play important pathophysiological roles, particularly in cancer. This review summarizes the composition and functions of PANoptosis and its associated PANoptosomes, including the ZBP1, RIPK1, AIM2, and NLRP12-PANoptosomes. Predictive models based on PANoptosis markers ha...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Journal of Bio-X Research |
| Online Access: | https://spj.science.org/doi/10.34133/jbioxresearch.0037 |
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| _version_ | 1850265278441586688 |
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| author | Yuqing Peng Huifang Zhao Chenxin Yang Xiangling Wang Shuai Zhang |
| author_facet | Yuqing Peng Huifang Zhao Chenxin Yang Xiangling Wang Shuai Zhang |
| author_sort | Yuqing Peng |
| collection | DOAJ |
| description | PANoptosis has been shown to play important pathophysiological roles, particularly in cancer. This review summarizes the composition and functions of PANoptosis and its associated PANoptosomes, including the ZBP1, RIPK1, AIM2, and NLRP12-PANoptosomes. Predictive models based on PANoptosis markers have been developed to guide personalized treatment strategies, highlighting novel therapeutic targets. Research into compounds that modulate PANoptosis pathways is ongoing, with the aim of increasing cancer treatment efficacy and addressing challenges such as drug resistance and immune evasion. This review also summarizes innovative PANoptosis-related prognostic gene signature models and compounds that modulate PANoptosis pathways. |
| format | Article |
| id | doaj-art-509ab75579df49429d0ec0b1900d45d0 |
| institution | OA Journals |
| issn | 2577-3585 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Journal of Bio-X Research |
| spelling | doaj-art-509ab75579df49429d0ec0b1900d45d02025-08-20T01:54:29ZengAmerican Association for the Advancement of Science (AAAS)Journal of Bio-X Research2577-35852025-01-01810.34133/jbioxresearch.0037PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic ImplicationsYuqing Peng0Huifang Zhao1Chenxin Yang2Xiangling Wang3Shuai Zhang4School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.PANoptosis has been shown to play important pathophysiological roles, particularly in cancer. This review summarizes the composition and functions of PANoptosis and its associated PANoptosomes, including the ZBP1, RIPK1, AIM2, and NLRP12-PANoptosomes. Predictive models based on PANoptosis markers have been developed to guide personalized treatment strategies, highlighting novel therapeutic targets. Research into compounds that modulate PANoptosis pathways is ongoing, with the aim of increasing cancer treatment efficacy and addressing challenges such as drug resistance and immune evasion. This review also summarizes innovative PANoptosis-related prognostic gene signature models and compounds that modulate PANoptosis pathways.https://spj.science.org/doi/10.34133/jbioxresearch.0037 |
| spellingShingle | Yuqing Peng Huifang Zhao Chenxin Yang Xiangling Wang Shuai Zhang PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications Journal of Bio-X Research |
| title | PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications |
| title_full | PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications |
| title_fullStr | PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications |
| title_full_unstemmed | PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications |
| title_short | PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications |
| title_sort | panoptosis in cancer molecular mechanism current evidence and therapeutic implications |
| url | https://spj.science.org/doi/10.34133/jbioxresearch.0037 |
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