Individual variability in cortical representations of tonic pain
When people experience pain in everyday situations, the experience is often long-lasting and fluctuating. However, pain research predominantly focuses on artificial brief and repeated singular painful events.Here, we aimed to approximate clinically relevant pain in 152 sessions from 38 participants...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025008382 |
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| author | Bettina Deak Anne Stankewitz Astrid Mayr Viktor Witkovsky Pauline Jahn Enrico Schulz |
| author_facet | Bettina Deak Anne Stankewitz Astrid Mayr Viktor Witkovsky Pauline Jahn Enrico Schulz |
| author_sort | Bettina Deak |
| collection | DOAJ |
| description | When people experience pain in everyday situations, the experience is often long-lasting and fluctuating. However, pain research predominantly focuses on artificial brief and repeated singular painful events.Here, we aimed to approximate clinically relevant pain in 152 sessions from 38 participants who underwent four sessions each. We applied variable levels of contact heat pain to the forearm using a thermode. Participants were asked to continuously rate their pain experience through a potentiometer device. In a whole-brain approach, we related the dynamic fluctuations of cortical activity and connectivity to the time courses of pain. We also explored the variability of cortical processing across participants. In an individual approach, we compared the cortical processing pattern of each individual with the overall group findings.The results revealed a large discrepancy between the group results that are usually reported in publications and the 4-session individual processing patterns: the group findings corroborated previous work localising tonic pain encoding to the secondary somatosensory cortex. By contrast, this region was shadowed by a variety of activity patterns across individuals, represented by a low spatial correlation between group statistics and individual results.The current findings challenge the usefulness and applicability of group results. They do not inform us how pain is processed in the brain as none of the participants exhibited the processing pattern of the group statistics. Therapies to relieve pain that rely on the modulation of brain regions will fail unless they are adapted to an individual's unique pain processing characteristics. |
| format | Article |
| id | doaj-art-50983f1fe9ea4d579c9cc0890bda1da7 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-50983f1fe9ea4d579c9cc0890bda1da72025-02-09T05:00:41ZengElsevierHeliyon2405-84402025-02-01113e42458Individual variability in cortical representations of tonic painBettina Deak0Anne Stankewitz1Astrid Mayr2Viktor Witkovsky3Pauline Jahn4Enrico Schulz5Department of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, GermanyDepartment of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, GermanyDepartment of Theoretical Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovak RepublicDepartment of Neurology, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, GermanyDepartment of Radiology, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany; Department of Medical Psychology, Ludwig-Maximilians-Universität München, Munich, Germany; Corresponding author. Ludwig-Maximilians-Universität München, Klinik und Poliklinik für Radiologie Marchioninistr. 15, 81377, München, Germany.When people experience pain in everyday situations, the experience is often long-lasting and fluctuating. However, pain research predominantly focuses on artificial brief and repeated singular painful events.Here, we aimed to approximate clinically relevant pain in 152 sessions from 38 participants who underwent four sessions each. We applied variable levels of contact heat pain to the forearm using a thermode. Participants were asked to continuously rate their pain experience through a potentiometer device. In a whole-brain approach, we related the dynamic fluctuations of cortical activity and connectivity to the time courses of pain. We also explored the variability of cortical processing across participants. In an individual approach, we compared the cortical processing pattern of each individual with the overall group findings.The results revealed a large discrepancy between the group results that are usually reported in publications and the 4-session individual processing patterns: the group findings corroborated previous work localising tonic pain encoding to the secondary somatosensory cortex. By contrast, this region was shadowed by a variety of activity patterns across individuals, represented by a low spatial correlation between group statistics and individual results.The current findings challenge the usefulness and applicability of group results. They do not inform us how pain is processed in the brain as none of the participants exhibited the processing pattern of the group statistics. Therapies to relieve pain that rely on the modulation of brain regions will fail unless they are adapted to an individual's unique pain processing characteristics.http://www.sciencedirect.com/science/article/pii/S2405844025008382 |
| spellingShingle | Bettina Deak Anne Stankewitz Astrid Mayr Viktor Witkovsky Pauline Jahn Enrico Schulz Individual variability in cortical representations of tonic pain Heliyon |
| title | Individual variability in cortical representations of tonic pain |
| title_full | Individual variability in cortical representations of tonic pain |
| title_fullStr | Individual variability in cortical representations of tonic pain |
| title_full_unstemmed | Individual variability in cortical representations of tonic pain |
| title_short | Individual variability in cortical representations of tonic pain |
| title_sort | individual variability in cortical representations of tonic pain |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025008382 |
| work_keys_str_mv | AT bettinadeak individualvariabilityincorticalrepresentationsoftonicpain AT annestankewitz individualvariabilityincorticalrepresentationsoftonicpain AT astridmayr individualvariabilityincorticalrepresentationsoftonicpain AT viktorwitkovsky individualvariabilityincorticalrepresentationsoftonicpain AT paulinejahn individualvariabilityincorticalrepresentationsoftonicpain AT enricoschulz individualvariabilityincorticalrepresentationsoftonicpain |