Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all poultr...
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Wiley
2023-06-01
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| Online Access: | https://doi.org/10.2903/j.efsa.2023.8047 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Jordi Ortuño Casanova |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Jordi Ortuño Casanova |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all poultry. In a previous opinion, the FEEDAP Panel concluded that Xygest™ HT is safe for all poultry, consumers, and the environment. The additive is not considered to be irritant to eyes and skin but a dermal and a respiratory sensitiser, although exposure by inhalation is unlikely. The Panel also concluded that the additive has the potential to be efficacious in laying hens at 45,000 U/kg complete feed and this conclusion was extrapolated to all laying poultry. However, the Panel could not conclude on the efficacy of the product in growing poultry at the proposed conditions of use. In the current application, the applicant provided an additional efficacy trial in chickens for fattening. The results showed a higher apparent metabolisable energy (nitrogen corrected) in chickens fed the additive at the minimum proposed level of 30,000 U/kg complete feed when compared to the control group. Considering the previously submitted studies in laying hens and chickens for fattening, and the newly submitted study in chickens for fattening, the Panel concluded that Xygest™ HT has the potential to be efficacious to enhance digestibility in all poultry at the corresponding proposed minimum levels in feed. |
| format | Article |
| id | doaj-art-50974c843d644207b7315eb95ea0f3c6 |
| institution | DOAJ |
| issn | 1831-4732 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-50974c843d644207b7315eb95ea0f3c62025-08-20T03:09:02ZengWileyEFSA Journal1831-47322023-06-01216n/an/a10.2903/j.efsa.2023.8047Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenMojca DurjavaBirgit DusemundMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosYolanda SanzRoberto Edoardo VillaRuud WoutersenJordi Ortuño CasanovaAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all poultry. In a previous opinion, the FEEDAP Panel concluded that Xygest™ HT is safe for all poultry, consumers, and the environment. The additive is not considered to be irritant to eyes and skin but a dermal and a respiratory sensitiser, although exposure by inhalation is unlikely. The Panel also concluded that the additive has the potential to be efficacious in laying hens at 45,000 U/kg complete feed and this conclusion was extrapolated to all laying poultry. However, the Panel could not conclude on the efficacy of the product in growing poultry at the proposed conditions of use. In the current application, the applicant provided an additional efficacy trial in chickens for fattening. The results showed a higher apparent metabolisable energy (nitrogen corrected) in chickens fed the additive at the minimum proposed level of 30,000 U/kg complete feed when compared to the control group. Considering the previously submitted studies in laying hens and chickens for fattening, and the newly submitted study in chickens for fattening, the Panel concluded that Xygest™ HT has the potential to be efficacious to enhance digestibility in all poultry at the corresponding proposed minimum levels in feed.https://doi.org/10.2903/j.efsa.2023.8047zootechnical additivesdigestibility enhancersXygest HTendo‐1,4‐beta‐xylanaseK. phaffii ATCC PTA‐127053poultry |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Jordi Ortuño Casanova Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.) EFSA Journal zootechnical additives digestibility enhancers Xygest HT endo‐1,4‐beta‐xylanase K. phaffii ATCC PTA‐127053 poultry |
| title | Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.) |
| title_full | Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.) |
| title_fullStr | Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.) |
| title_full_unstemmed | Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.) |
| title_short | Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.) |
| title_sort | efficacy of a feed additive consisting of endo 1 4 beta xylanase produced by komagataella phaffii atcc pta 127053 xygest™ ht for all poultry species kemin europa n v |
| topic | zootechnical additives digestibility enhancers Xygest HT endo‐1,4‐beta‐xylanase K. phaffii ATCC PTA‐127053 poultry |
| url | https://doi.org/10.2903/j.efsa.2023.8047 |
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