Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration
The incidence of severe ischemic heart disease caused by coronary obstruction has progressively increased. Alternative forms of treatment have been studied in an attempt to regenerate myocardial tissue, induce angiogenesis, and improve clinical conditions. In this context, cell therapy has emerged a...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/2171035 |
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| _version_ | 1849406696903933952 |
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| author | Maximiliano I. Schaun Bruna Eibel Melissa Kristocheck Grasiele Sausen Luana Machado Andreia Koche Melissa M. Markoski |
| author_facet | Maximiliano I. Schaun Bruna Eibel Melissa Kristocheck Grasiele Sausen Luana Machado Andreia Koche Melissa M. Markoski |
| author_sort | Maximiliano I. Schaun |
| collection | DOAJ |
| description | The incidence of severe ischemic heart disease caused by coronary obstruction has progressively increased. Alternative forms of treatment have been studied in an attempt to regenerate myocardial tissue, induce angiogenesis, and improve clinical conditions. In this context, cell therapy has emerged as a promising alternative using cells with regenerative potential, focusing on the release of paracrine and autocrine factors that contribute to cell survival, angiogenesis, and tissue remodeling. Evidence of the safety, feasibility, and potential effectiveness of cell therapy has emerged from several clinical trials using different lineages of adult stem cells. The clinical benefit, however, is not yet well established. In this review, we discuss the therapeutic potential of cell therapy in terms of regenerative and angiogenic capacity after myocardial ischemia. In addition, we addressed nonpharmacological interventions that may influence this therapeutic practice, such as diet and physical training. This review brings together current data on pharmacological and nonpharmacological approaches to improve cell homing and cardiac repair. |
| format | Article |
| id | doaj-art-5095f1c236f940f5aae6840e73dcb1db |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5095f1c236f940f5aae6840e73dcb1db2025-08-20T03:36:18ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/21710352171035Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac RegenerationMaximiliano I. Schaun0Bruna Eibel1Melissa Kristocheck2Grasiele Sausen3Luana Machado4Andreia Koche5Melissa M. Markoski6Laboratório de Cardiologia Molecular e Celular (LCMC), Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, BrazilLaboratório de Cardiologia Molecular e Celular (LCMC), Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, BrazilLaboratório de Cardiologia Molecular e Celular (LCMC), Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, BrazilLaboratório de Cardiologia Molecular e Celular (LCMC), Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, BrazilLaboratório de Cardiologia Molecular e Celular (LCMC), Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, BrazilLaboratório de Cardiologia Molecular e Celular (LCMC), Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, BrazilLaboratório de Cardiologia Molecular e Celular (LCMC), Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, BrazilThe incidence of severe ischemic heart disease caused by coronary obstruction has progressively increased. Alternative forms of treatment have been studied in an attempt to regenerate myocardial tissue, induce angiogenesis, and improve clinical conditions. In this context, cell therapy has emerged as a promising alternative using cells with regenerative potential, focusing on the release of paracrine and autocrine factors that contribute to cell survival, angiogenesis, and tissue remodeling. Evidence of the safety, feasibility, and potential effectiveness of cell therapy has emerged from several clinical trials using different lineages of adult stem cells. The clinical benefit, however, is not yet well established. In this review, we discuss the therapeutic potential of cell therapy in terms of regenerative and angiogenic capacity after myocardial ischemia. In addition, we addressed nonpharmacological interventions that may influence this therapeutic practice, such as diet and physical training. This review brings together current data on pharmacological and nonpharmacological approaches to improve cell homing and cardiac repair.http://dx.doi.org/10.1155/2016/2171035 |
| spellingShingle | Maximiliano I. Schaun Bruna Eibel Melissa Kristocheck Grasiele Sausen Luana Machado Andreia Koche Melissa M. Markoski Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration Stem Cells International |
| title | Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration |
| title_full | Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration |
| title_fullStr | Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration |
| title_full_unstemmed | Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration |
| title_short | Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration |
| title_sort | cell therapy in ischemic heart disease interventions that modulate cardiac regeneration |
| url | http://dx.doi.org/10.1155/2016/2171035 |
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