The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity
A number of 2-substituted benzimidazoles has been prepared and the compounds were characterized by their physico-chemical and spectral properties. - Mutagenicity tests with two strains of Salmonella typhimurium revealed that on one hand the mutagenic activity of these compounds tends to parallel th...
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| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1973-02-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9060 |
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| _version_ | 1850140280866471936 |
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| author | J.P. Seiler H. Limacher |
| author_facet | J.P. Seiler H. Limacher |
| author_sort | J.P. Seiler |
| collection | DOAJ |
| description |
A number of 2-substituted benzimidazoles has been prepared and the compounds were characterized by their physico-chemical and spectral properties. - Mutagenicity tests with two strains of Salmonella typhimurium revealed that on one hand the mutagenic activity of these compounds tends to parallel their respective pKa's, but that on the other hand the benzimidazoles with larger sized 2-substituents are comparatively less active mutagenic compounds.
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| format | Article |
| id | doaj-art-50932a9d9ebf4bc3a362336e030b332f |
| institution | OA Journals |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 1973-02-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-50932a9d9ebf4bc3a362336e030b332f2025-08-20T02:29:54ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241973-02-0127210.2533/chimia.1973.68The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activityJ.P. Seiler0H. Limacher1Swiss Federal Research Station for Arboriculture, Viticulture and Horticulture, CH-8820 Wädenswil (Switzerland)Swiss Federal Research Station for Arboriculture, Viticulture and Horticulture, CH-8820 Wädenswil (Switzerland) A number of 2-substituted benzimidazoles has been prepared and the compounds were characterized by their physico-chemical and spectral properties. - Mutagenicity tests with two strains of Salmonella typhimurium revealed that on one hand the mutagenic activity of these compounds tends to parallel their respective pKa's, but that on the other hand the benzimidazoles with larger sized 2-substituents are comparatively less active mutagenic compounds. https://www.chimia.ch/chimia/article/view/9060 |
| spellingShingle | J.P. Seiler H. Limacher The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity CHIMIA |
| title | The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity |
| title_full | The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity |
| title_fullStr | The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity |
| title_full_unstemmed | The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity |
| title_short | The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity |
| title_sort | mutagenicity of benzimidazole and benzimidazole derivatives iii the influence of the 2 substituent in benzimidazole on the mutagenic activity |
| url | https://www.chimia.ch/chimia/article/view/9060 |
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