Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood

BackgroundOur group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of endogenous plasmin within thrombi. However, the...

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Bibliographic Details
Main Authors: Laurence Vincent, Catherine Lapointe, Patrick P. McDonald, Christos Rammos, Tienush Rassaf, Maria Köllnberger, Hanna Tinel, Stefan Heitmeier, Pedro D’Orléans-Juste
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1511990/full
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