Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic
Introduction Almost half of all school-age children with bronchopulmonary dysplasia (BPD) have asthma-like symptoms and more suffer from lung function deficits. While air pollution and indoor respiratory irritants are known to affect high-risk populations of children, few studies have objectively ev...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021-11-01
|
| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/8/1/e000915.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850181556695465984 |
|---|---|
| author | Jose Vallarino Gary Adamkiewicz Wanda Phipatanakul Lystra P Hayden Hana B Ruran Amparito Cunningham Carter R Petty Kimberly F Greco Sigfus Gunnlaugsson Natalie Stamatiadis Gabriella Sierra Marty Alvarez Catherine A Sheils Edie Weller Jonathan M Gaffin |
| author_facet | Jose Vallarino Gary Adamkiewicz Wanda Phipatanakul Lystra P Hayden Hana B Ruran Amparito Cunningham Carter R Petty Kimberly F Greco Sigfus Gunnlaugsson Natalie Stamatiadis Gabriella Sierra Marty Alvarez Catherine A Sheils Edie Weller Jonathan M Gaffin |
| author_sort | Jose Vallarino |
| collection | DOAJ |
| description | Introduction Almost half of all school-age children with bronchopulmonary dysplasia (BPD) have asthma-like symptoms and more suffer from lung function deficits. While air pollution and indoor respiratory irritants are known to affect high-risk populations of children, few studies have objectively evaluated environmental contributions to long-term respiratory morbidity in this population. This study aimed to examine the role of indoor environmental exposures on respiratory morbidity in children with BPD.Methods and analysis The Air quality, Environment and Respiratory Ouctomes in BPD (AERO-BPD) study is a prospective, single-centre observational study that will enrol a unique cohort of 240 children with BPD and carefully characterise participants and their indoor home environmental exposures. Measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), nitric oxide (NO), temperature and humidity, as well as dust concentrations of allergens, with concurrently measured respiratory symptoms and lung function.Adaptations to the research protocol due to the SARS-CoV-2 pandemic included remote home environment and participant assessments.Ethics and dissemination Study protocol was approved by the Boston Children’s Hospital Committee on Clinical Investigation. Dissemination will be in the form of peer-reviewed publications and participant information products.Trial registration number NCT04107701. |
| format | Article |
| id | doaj-art-507ed021abe94e6fa6eb2bfe73991843 |
| institution | OA Journals |
| issn | 2052-4439 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-507ed021abe94e6fa6eb2bfe739918432025-08-20T02:17:52ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392021-11-018110.1136/bmjresp-2021-000915Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemicJose Vallarino0Gary Adamkiewicz1Wanda Phipatanakul2Lystra P Hayden3Hana B Ruran4Amparito Cunningham5Carter R Petty6Kimberly F Greco7Sigfus Gunnlaugsson8Natalie Stamatiadis9Gabriella Sierra10Marty Alvarez11Catherine A Sheils12Edie Weller13Jonathan M Gaffin14Department of Environmental Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USADepartment of Environmental Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USADivision of Allergy and Immunology, Boston Children’s Hospital, Boston, Massachusetts, USABoston Childrens Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USABoston Childrens Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USABoston Childrens Hospital Division of Immunology, Boston, Massachusetts, USABoston Childrens Hospital, Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston, Massachusetts, USAInstitutional Center of Clinical and Translational Research (ICCTR), Biostatistics and Research Design Center (BARD), Boston Children’s Hospital, Boston, Massachusetts, USABoston Childrens Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USABoston Childrens Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USABoston Childrens Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USADepartment of Environmental Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USABoston Childrens Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USABoston Childrens Hospital, Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston, Massachusetts, USABoston Childrens Hospital Division of Pulmonary and Respiratory Diseases, Boston, Massachusetts, USAIntroduction Almost half of all school-age children with bronchopulmonary dysplasia (BPD) have asthma-like symptoms and more suffer from lung function deficits. While air pollution and indoor respiratory irritants are known to affect high-risk populations of children, few studies have objectively evaluated environmental contributions to long-term respiratory morbidity in this population. This study aimed to examine the role of indoor environmental exposures on respiratory morbidity in children with BPD.Methods and analysis The Air quality, Environment and Respiratory Ouctomes in BPD (AERO-BPD) study is a prospective, single-centre observational study that will enrol a unique cohort of 240 children with BPD and carefully characterise participants and their indoor home environmental exposures. Measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), nitric oxide (NO), temperature and humidity, as well as dust concentrations of allergens, with concurrently measured respiratory symptoms and lung function.Adaptations to the research protocol due to the SARS-CoV-2 pandemic included remote home environment and participant assessments.Ethics and dissemination Study protocol was approved by the Boston Children’s Hospital Committee on Clinical Investigation. Dissemination will be in the form of peer-reviewed publications and participant information products.Trial registration number NCT04107701.https://bmjopenrespres.bmj.com/content/8/1/e000915.full |
| spellingShingle | Jose Vallarino Gary Adamkiewicz Wanda Phipatanakul Lystra P Hayden Hana B Ruran Amparito Cunningham Carter R Petty Kimberly F Greco Sigfus Gunnlaugsson Natalie Stamatiadis Gabriella Sierra Marty Alvarez Catherine A Sheils Edie Weller Jonathan M Gaffin Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic BMJ Open Respiratory Research |
| title | Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic |
| title_full | Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic |
| title_fullStr | Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic |
| title_full_unstemmed | Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic |
| title_short | Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic |
| title_sort | air quality environment and respiratory outcomes in bronchopulmonary dysplasia the aero bpd cohort study design and adaptation during the sars cov 2 pandemic |
| url | https://bmjopenrespres.bmj.com/content/8/1/e000915.full |
| work_keys_str_mv | AT josevallarino airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT garyadamkiewicz airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT wandaphipatanakul airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT lystraphayden airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT hanabruran airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT amparitocunningham airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT carterrpetty airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT kimberlyfgreco airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT sigfusgunnlaugsson airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT nataliestamatiadis airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT gabriellasierra airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT martyalvarez airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT catherineasheils airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT edieweller airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic AT jonathanmgaffin airqualityenvironmentandrespiratoryoutcomesinbronchopulmonarydysplasiatheaerobpdcohortstudydesignandadaptationduringthesarscov2pandemic |