The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling
IntroductionAbdominal Aortic Aneurysm (AAA) is a common vascular disease characterized by progressive expansion and remodeling of the aortic wall. However, with the gradual expansion of blood vessels, the walls of blood vessels cannot withstand the tension and rupture, jeopardizing people’s health.M...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1560193/full |
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| author | Wenqi Qin Dan Qiao Mingming Ren Xiaoqiang Ye Guanghao Yu Guangxin Chen Jian Xing Wei Ma Miao Yu Xiaohuan Yuan Kunfu Ouyang Wenchang Tan Wenchang Tan Wenchang Tan Dongliang Zhao |
| author_facet | Wenqi Qin Dan Qiao Mingming Ren Xiaoqiang Ye Guanghao Yu Guangxin Chen Jian Xing Wei Ma Miao Yu Xiaohuan Yuan Kunfu Ouyang Wenchang Tan Wenchang Tan Wenchang Tan Dongliang Zhao |
| author_sort | Wenqi Qin |
| collection | DOAJ |
| description | IntroductionAbdominal Aortic Aneurysm (AAA) is a common vascular disease characterized by progressive expansion and remodeling of the aortic wall. However, with the gradual expansion of blood vessels, the walls of blood vessels cannot withstand the tension and rupture, jeopardizing people’s health.MethodsThe aim of the experiment was to establish an abdominal aortic aneurysm model in rats by applying porcine pancreatic elastase externally, to measure the diameter and thickness of blood vessels as well as hemodynamics using animal ultrasound, to measure the active contraction of blood vessels, the rate of contraction, and the contraction stress using vascular mechanics equipment, and to observe the pathological changes in the process of AAA growth using vascular pathological staining.ResultsThis study revealed that with the escalation of the inflammatory response, there is a breakdown of elastic fibers and collagen fibers, leading to a decrease in the active contraction force of the arteries. However, it was observed that by alleviating the inflammation, there was a notable enhancement in the active contraction force of the arteries.Discussion:To describe the development process of AAA from a biomechanical point of view, to reveal the histopathological mechanism, and thus to identify the theoretical basis for clinical treatment. |
| format | Article |
| id | doaj-art-507d3fb3b72941f1a7efe3706f6faf3e |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-507d3fb3b72941f1a7efe3706f6faf3e2025-08-20T02:40:47ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-03-011310.3389/fbioe.2025.15601931560193The active mechanical characteristics of arterial smooth muscle during aneurysm remodelingWenqi Qin0Dan Qiao1Mingming Ren2Xiaoqiang Ye3Guanghao Yu4Guangxin Chen5Jian Xing6Wei Ma7Miao Yu8Xiaohuan Yuan9Kunfu Ouyang10Wenchang Tan11Wenchang Tan12Wenchang Tan13Dongliang Zhao14School of Life Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang, ChinaDepartment of Pathology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaMedical Image College, Mudanjiang Medical University, Mudanjiang, Heilongjiang, ChinaMedical Image College, Mudanjiang Medical University, Mudanjiang, Heilongjiang, ChinaMedical Image College, Mudanjiang Medical University, Mudanjiang, Heilongjiang, ChinaBasic Medical School, Mudanjiang Medical University, Mudanjiang, Heilongjiang, ChinaPeking University Shenzhen Graduate School, Shenzhen Bay Laboratory, Shenzhen, Guangdong, ChinaSchool of Life Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang, ChinaDepartment of Pathology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, ChinaPeking University Shenzhen Graduate School, Shenzhen Bay Laboratory, Shenzhen, Guangdong, ChinaPKU-HKUST Shenzhen-Hong Kong Institution, Shenzhen, Guangdong, ChinaDepartment of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, ChinaPeking University Shenzhen Graduate School, Shenzhen Bay Laboratory, Shenzhen, Guangdong, ChinaIntroductionAbdominal Aortic Aneurysm (AAA) is a common vascular disease characterized by progressive expansion and remodeling of the aortic wall. However, with the gradual expansion of blood vessels, the walls of blood vessels cannot withstand the tension and rupture, jeopardizing people’s health.MethodsThe aim of the experiment was to establish an abdominal aortic aneurysm model in rats by applying porcine pancreatic elastase externally, to measure the diameter and thickness of blood vessels as well as hemodynamics using animal ultrasound, to measure the active contraction of blood vessels, the rate of contraction, and the contraction stress using vascular mechanics equipment, and to observe the pathological changes in the process of AAA growth using vascular pathological staining.ResultsThis study revealed that with the escalation of the inflammatory response, there is a breakdown of elastic fibers and collagen fibers, leading to a decrease in the active contraction force of the arteries. However, it was observed that by alleviating the inflammation, there was a notable enhancement in the active contraction force of the arteries.Discussion:To describe the development process of AAA from a biomechanical point of view, to reveal the histopathological mechanism, and thus to identify the theoretical basis for clinical treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1560193/fullabdominal aortic aneurysmactive mechanical characteristicsgrowth remodelingsmooth musclevasospasm |
| spellingShingle | Wenqi Qin Dan Qiao Mingming Ren Xiaoqiang Ye Guanghao Yu Guangxin Chen Jian Xing Wei Ma Miao Yu Xiaohuan Yuan Kunfu Ouyang Wenchang Tan Wenchang Tan Wenchang Tan Dongliang Zhao The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling Frontiers in Bioengineering and Biotechnology abdominal aortic aneurysm active mechanical characteristics growth remodeling smooth muscle vasospasm |
| title | The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling |
| title_full | The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling |
| title_fullStr | The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling |
| title_full_unstemmed | The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling |
| title_short | The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling |
| title_sort | active mechanical characteristics of arterial smooth muscle during aneurysm remodeling |
| topic | abdominal aortic aneurysm active mechanical characteristics growth remodeling smooth muscle vasospasm |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1560193/full |
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