Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular response
The Ti-6Al-4V alloy is widely recognized for its excellent properties, such as biocompatibility, corrosion resistance, and high mechanical strength, making it a popular choice for medical implants. This study focuses on the development of a composite coating consisting of bioactive glass (64SiO₂-31C...
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Elsevier
2025-06-01
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| Series: | Applied Surface Science Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266652392500042X |
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| author | Zahra Sohani Hamed Jamshidi Aval Sayed Mahmood Rabiee |
| author_facet | Zahra Sohani Hamed Jamshidi Aval Sayed Mahmood Rabiee |
| author_sort | Zahra Sohani |
| collection | DOAJ |
| description | The Ti-6Al-4V alloy is widely recognized for its excellent properties, such as biocompatibility, corrosion resistance, and high mechanical strength, making it a popular choice for medical implants. This study focuses on the development of a composite coating consisting of bioactive glass (64SiO₂-31CaO-5P₂O₅ mol%) and Fe₃O₄ nanoparticles, with a 5 wt% concentration, applied to the Ti-6Al-4V alloy through electrophoretic deposition. The investigation examined various characteristics, including the morphology, surface roughness, thickness, electrochemical behavior, wettability, and biological properties such as bioactivity, cell adhesion, and cytotoxicity of the samples. Scanning electron microscopy (SEM) analysis revealed that the average size of the bioactive glass particles was 3.06 ± 1.64 µm, which is suitable for the electrophoretic deposition process. The findings show that the addition of iron oxide nanoparticles improves the corrosion resistance of the substrate. To assess bioactivity, the samples were immersed in simulated body fluid (SBF) for 7, 14, and 28 days. SEM images and elemental distribution maps showed the presence of calcium and phosphorus on the surface, which is indicative of bioactive behavior. Moreover, the sample containing Fe₃O₄ nanoparticles exhibited significant increases in surface roughness and hydrophilicity, which enhanced cell adhesion. Interestingly, cell viability decreased within 3 days for the composite sample of bioactive glass with 5 wt% Fe₃O₄ nanoparticles, whereas the sample coated with bioactive glass alone (without iron oxide nanoparticles) showed favorable cell viability. |
| format | Article |
| id | doaj-art-50791b6a7f1b45d3a5f0ab192a170e23 |
| institution | DOAJ |
| issn | 2666-5239 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Applied Surface Science Advances |
| spelling | doaj-art-50791b6a7f1b45d3a5f0ab192a170e232025-08-20T03:10:39ZengElsevierApplied Surface Science Advances2666-52392025-06-012710073410.1016/j.apsadv.2025.100734Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular responseZahra Sohani0Hamed Jamshidi Aval1Sayed Mahmood Rabiee2Department of Materials Engineering, Babol Noshirvani University of Technology, Mazandaran, IranDepartment of Materials Engineering, Babol Noshirvani University of Technology, Mazandaran, IranCorresponding author.; Department of Materials Engineering, Babol Noshirvani University of Technology, Mazandaran, IranThe Ti-6Al-4V alloy is widely recognized for its excellent properties, such as biocompatibility, corrosion resistance, and high mechanical strength, making it a popular choice for medical implants. This study focuses on the development of a composite coating consisting of bioactive glass (64SiO₂-31CaO-5P₂O₅ mol%) and Fe₃O₄ nanoparticles, with a 5 wt% concentration, applied to the Ti-6Al-4V alloy through electrophoretic deposition. The investigation examined various characteristics, including the morphology, surface roughness, thickness, electrochemical behavior, wettability, and biological properties such as bioactivity, cell adhesion, and cytotoxicity of the samples. Scanning electron microscopy (SEM) analysis revealed that the average size of the bioactive glass particles was 3.06 ± 1.64 µm, which is suitable for the electrophoretic deposition process. The findings show that the addition of iron oxide nanoparticles improves the corrosion resistance of the substrate. To assess bioactivity, the samples were immersed in simulated body fluid (SBF) for 7, 14, and 28 days. SEM images and elemental distribution maps showed the presence of calcium and phosphorus on the surface, which is indicative of bioactive behavior. Moreover, the sample containing Fe₃O₄ nanoparticles exhibited significant increases in surface roughness and hydrophilicity, which enhanced cell adhesion. Interestingly, cell viability decreased within 3 days for the composite sample of bioactive glass with 5 wt% Fe₃O₄ nanoparticles, whereas the sample coated with bioactive glass alone (without iron oxide nanoparticles) showed favorable cell viability.http://www.sciencedirect.com/science/article/pii/S266652392500042XTi-6Al-4VBioactive glassFe3O4Electrophoretic depositionCoating |
| spellingShingle | Zahra Sohani Hamed Jamshidi Aval Sayed Mahmood Rabiee Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular response Applied Surface Science Advances Ti-6Al-4V Bioactive glass Fe3O4 Electrophoretic deposition Coating |
| title | Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular response |
| title_full | Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular response |
| title_fullStr | Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular response |
| title_full_unstemmed | Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular response |
| title_short | Bioactive glass and iron oxide nanoparticle composite coatings for Ti-6Al-4V implants: Microstructure, corrosion behavior, bioactivity and cellular response |
| title_sort | bioactive glass and iron oxide nanoparticle composite coatings for ti 6al 4v implants microstructure corrosion behavior bioactivity and cellular response |
| topic | Ti-6Al-4V Bioactive glass Fe3O4 Electrophoretic deposition Coating |
| url | http://www.sciencedirect.com/science/article/pii/S266652392500042X |
| work_keys_str_mv | AT zahrasohani bioactiveglassandironoxidenanoparticlecompositecoatingsforti6al4vimplantsmicrostructurecorrosionbehaviorbioactivityandcellularresponse AT hamedjamshidiaval bioactiveglassandironoxidenanoparticlecompositecoatingsforti6al4vimplantsmicrostructurecorrosionbehaviorbioactivityandcellularresponse AT sayedmahmoodrabiee bioactiveglassandironoxidenanoparticlecompositecoatingsforti6al4vimplantsmicrostructurecorrosionbehaviorbioactivityandcellularresponse |