Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia

Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia

Background Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD).Objective To investigate the diagnostic utility of the soluble N-ethylmaleimide-sensitive-factor attachment receptor (SNAR...

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Main Authors: Patrick Oeckl, Petra Steinacker, Markus Otto, Steffen Halbgebauer, MHD Rami Al Shweiki, Samir Abu-Rumeileh, Naguib Mechawar, Carlos Schönfeldt-Lecuona, Lorenzo Barba, Leonie Werner, Alexander Tarabuko, Ilyas Al-Ali, Christopher R Pryce, Nadia Cattane, Giulia Poggi, Heiko Graf, Henning Großkopf, Laura Meier, Hugh Marston, Klaus D Bornemann, Bastian Hengerer, Karin M Danzer
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Mental Health
Online Access:https://mentalhealth.bmj.com/content/28/1/e301752.full
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