Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction
Chronic heart failure (CHF) is one of the most significant health, economic and social problems of the XXI century. Aim. To identify predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction taking into account the results of...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2016-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/76914/73857 |
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| _version_ | 1849700722824708096 |
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| author | D. A. Lashkul |
| author_facet | D. A. Lashkul |
| author_sort | D. A. Lashkul |
| collection | DOAJ |
| description | Chronic heart failure (CHF) is one of the most significant health, economic and social problems of the XXI century.
Aim. To identify predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction taking into account the results of three years observation.
Materials and methods. In order to reveal prognostic factors of adverse events, 140 patients (81.4% men, mean age 60 (54.5–68) years) with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction were investigated. For determination of dependent and independent prognostic factors of adverse events ROC-analysis, univariate and multivariate Cox proportional hazard regression analyses were done.
Results. In order to determine independent predictors of major adverse cardiovascular events 18 hazards indicators were analyzed using Cox proportional. By results of multivariate regression analysis Cox proportional hazards found that the optimal cut-off point in excess distribution age>65 years, the risk of cumulative endpoint in patients with ischemic heart failure significantly increased in 2.75 times (95% CI 1.67–4.50; p=0.001), heart rate>79 beats minute – in 2.26 times (95% CI 1.32–3.87, p=0.002) and the presence of lower than optimal point distribution values SAP≤140 mmHg – the risk is increased 1.83-fold (95% CI 1.02–3.64, p=0.03), eGFR≤70.27 ml/min/1,73m2 – at 1.73 times (95% CI 1.09–2.75; p=0.02), EF≤34,23% – to 1.94 times (95% CI 1.21–3.11, p=0.005), HDL≤0.86 mmol/l – 1.83 times (95% CI 1.12–2.99, p=0.01).
Conclusion. It was revealed that in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction within three years of observation there are such independent predictors of adverse cardiovascular events as age, heart rate, systolic blood pressure, glomerular filtration rate, left ventricular ejection fraction and HDL levels. |
| format | Article |
| id | doaj-art-5075773328a04337a3d67f391eb5e42b |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-5075773328a04337a3d67f391eb5e42b2025-08-20T03:18:11ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102016-06-01349Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunctionD. A. LashkulChronic heart failure (CHF) is one of the most significant health, economic and social problems of the XXI century. Aim. To identify predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction taking into account the results of three years observation. Materials and methods. In order to reveal prognostic factors of adverse events, 140 patients (81.4% men, mean age 60 (54.5–68) years) with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction were investigated. For determination of dependent and independent prognostic factors of adverse events ROC-analysis, univariate and multivariate Cox proportional hazard regression analyses were done. Results. In order to determine independent predictors of major adverse cardiovascular events 18 hazards indicators were analyzed using Cox proportional. By results of multivariate regression analysis Cox proportional hazards found that the optimal cut-off point in excess distribution age>65 years, the risk of cumulative endpoint in patients with ischemic heart failure significantly increased in 2.75 times (95% CI 1.67–4.50; p=0.001), heart rate>79 beats minute – in 2.26 times (95% CI 1.32–3.87, p=0.002) and the presence of lower than optimal point distribution values SAP≤140 mmHg – the risk is increased 1.83-fold (95% CI 1.02–3.64, p=0.03), eGFR≤70.27 ml/min/1,73m2 – at 1.73 times (95% CI 1.09–2.75; p=0.02), EF≤34,23% – to 1.94 times (95% CI 1.21–3.11, p=0.005), HDL≤0.86 mmol/l – 1.83 times (95% CI 1.12–2.99, p=0.01). Conclusion. It was revealed that in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction within three years of observation there are such independent predictors of adverse cardiovascular events as age, heart rate, systolic blood pressure, glomerular filtration rate, left ventricular ejection fraction and HDL levels.http://zmj.zsmu.edu.ua/article/view/76914/73857Heart FailurePredictorsKidney |
| spellingShingle | D. A. Lashkul Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction Zaporožskij Medicinskij Žurnal Heart Failure Predictors Kidney |
| title | Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction |
| title_full | Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction |
| title_fullStr | Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction |
| title_full_unstemmed | Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction |
| title_short | Predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction |
| title_sort | predictors of adverse events in patients with ischemic chronic heart failure with reduced ejection fraction and renal dysfunction |
| topic | Heart Failure Predictors Kidney |
| url | http://zmj.zsmu.edu.ua/article/view/76914/73857 |
| work_keys_str_mv | AT dalashkul predictorsofadverseeventsinpatientswithischemicchronicheartfailurewithreducedejectionfractionandrenaldysfunction |