Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases
Patients with rheumatic diseases have an increased risk of mortality by cardiovascular events. In fact, several rheumatic diseases such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis are associated with a higher prevalence of cardiovascular diseases...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/125458 |
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| author | Morena Scotece Javier Conde Rodolfo Gómez Verónica López Jesús Pino Antonio González Francisca Lago Juan J. Gómez-Reino Oreste Gualillo |
| author_facet | Morena Scotece Javier Conde Rodolfo Gómez Verónica López Jesús Pino Antonio González Francisca Lago Juan J. Gómez-Reino Oreste Gualillo |
| author_sort | Morena Scotece |
| collection | DOAJ |
| description | Patients with rheumatic diseases have an increased risk of mortality by cardiovascular events. In fact, several rheumatic diseases such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis are associated with a higher prevalence of cardiovascular diseases (CVDs). Although traditional cardiovascular risk factors have been involved in the pathogenesis of cardiovascular diseases in rheumatic patients, these alterations do not completely explain the enhanced cardiovascular risk in this population. Obesity and its pathologic alteration of fat mass and dysfunction, due to an altered pattern of secretion of proinflammatory adipokines, could be one of the links between cardiovascular and rheumatic diseases. Indeed, the incidence of CVDs is augmented in obese individuals with rheumatic disorders. Thus, in this paper we explore in detail the relationships among adipokines, rheumatic diseases, and cardiovascular complications by giving to the reader a holistic vision and several suggestions for future perspectives and potential clinical implications. |
| format | Article |
| id | doaj-art-5071f42be52e422bbdfc8f9bbf5fa8ba |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5071f42be52e422bbdfc8f9bbf5fa8ba2025-08-20T02:05:10ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/125458125458Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic DiseasesMorena Scotece0Javier Conde1Rodolfo Gómez2Verónica López3Jesús Pino4Antonio González5Francisca Lago6Juan J. Gómez-Reino7Oreste Gualillo8SERGAS, Santiago University Clinical Hospital and NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, SpainSERGAS, Santiago University Clinical Hospital and NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, SpainDivision of Rheumatology, Fundación Jiménez Diaz, 2-28040 Madrid, SpainSERGAS, Santiago University Clinical Hospital and NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, SpainSERGAS, Santiago University Clinical Hospital and Division of Orthopaedics Surgery and Traumatology, 15706 Santiago de Compostela, SpainSERGAS, Santiago University Clinical Hospital and Laboratory of Genetics in Rheumatic Diseases, Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, SpainSERGAS, Santiago University Clinical Hospital and Research Laboratory 7 (Molecular and Cellular Cardiology), Institute of Medical Research (IDIS), 15706 Santiago de Compostela, SpainSERGAS, Santiago University Clinical Hospital and NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, SpainSERGAS, Santiago University Clinical Hospital and NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Building C, Level-2, 15706 Santiago de Compostela, SpainPatients with rheumatic diseases have an increased risk of mortality by cardiovascular events. In fact, several rheumatic diseases such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis are associated with a higher prevalence of cardiovascular diseases (CVDs). Although traditional cardiovascular risk factors have been involved in the pathogenesis of cardiovascular diseases in rheumatic patients, these alterations do not completely explain the enhanced cardiovascular risk in this population. Obesity and its pathologic alteration of fat mass and dysfunction, due to an altered pattern of secretion of proinflammatory adipokines, could be one of the links between cardiovascular and rheumatic diseases. Indeed, the incidence of CVDs is augmented in obese individuals with rheumatic disorders. Thus, in this paper we explore in detail the relationships among adipokines, rheumatic diseases, and cardiovascular complications by giving to the reader a holistic vision and several suggestions for future perspectives and potential clinical implications.http://dx.doi.org/10.1155/2012/125458 |
| spellingShingle | Morena Scotece Javier Conde Rodolfo Gómez Verónica López Jesús Pino Antonio González Francisca Lago Juan J. Gómez-Reino Oreste Gualillo Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases Mediators of Inflammation |
| title | Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases |
| title_full | Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases |
| title_fullStr | Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases |
| title_full_unstemmed | Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases |
| title_short | Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases |
| title_sort | role of adipokines in atherosclerosis interferences with cardiovascular complications in rheumatic diseases |
| url | http://dx.doi.org/10.1155/2012/125458 |
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