Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma
Background: Polycystic ovary syndrome is a female reproductive system disease closely related to endocrine and highly correlated with the development of endometrial carcinoma in women, it is important to identify the key genes involved in the development of polycystic ovary syndrome. Methods: To ide...
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IMR Press
2021-10-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805180 |
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| author | Zhenzhen Lu Ying Gao |
| author_facet | Zhenzhen Lu Ying Gao |
| author_sort | Zhenzhen Lu |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome is a female reproductive system disease closely related to endocrine and highly correlated with the development of endometrial carcinoma in women, it is important to identify the key genes involved in the development of polycystic ovary syndrome. Methods: To identify the hub genes, microarray datasets GSE48301, GSE115810 and GSE3013 were downloaded from Gene Expression Omnibus database. We performed in-depth cross-tabulation bioinformatic analysis to identify differentially expressed genes (DEGs) among four types of endometrial cells in GSE48301 and two endometrial carcinoma datasets GSE115810 and GSE3013, followed by gene ontology, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment, protein-protein interaction network analysis. Results: Thirteen seed DEGs and 4 significantly expressed DEGs were identified, and potential drugs and mRNAs were found. Conclusion: EDNRA, FBN1, PMP22, SPARC and IGF-1 may be potential and their miRNAs, especially hsa-miR-29a-3p and hsa-miR-29b-3p may be potential biomarkers in the progression from PCOS to endometrial carcinoma. |
| format | Article |
| id | doaj-art-50716dfb792f445b899d8f131900a7e0 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-50716dfb792f445b899d8f131900a7e02025-08-20T01:56:42ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-10-014851117112510.31083/j.ceog4805180S0390-6663(21)00019-1Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinomaZhenzhen Lu0Ying Gao1Department of Gynaecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, ChinaDepartment of Gynaecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, ChinaBackground: Polycystic ovary syndrome is a female reproductive system disease closely related to endocrine and highly correlated with the development of endometrial carcinoma in women, it is important to identify the key genes involved in the development of polycystic ovary syndrome. Methods: To identify the hub genes, microarray datasets GSE48301, GSE115810 and GSE3013 were downloaded from Gene Expression Omnibus database. We performed in-depth cross-tabulation bioinformatic analysis to identify differentially expressed genes (DEGs) among four types of endometrial cells in GSE48301 and two endometrial carcinoma datasets GSE115810 and GSE3013, followed by gene ontology, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment, protein-protein interaction network analysis. Results: Thirteen seed DEGs and 4 significantly expressed DEGs were identified, and potential drugs and mRNAs were found. Conclusion: EDNRA, FBN1, PMP22, SPARC and IGF-1 may be potential and their miRNAs, especially hsa-miR-29a-3p and hsa-miR-29b-3p may be potential biomarkers in the progression from PCOS to endometrial carcinoma.https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805180differentially expressed genesendometrial carcinomainsulin-like growth factor 1polycystic ovary syndrome |
| spellingShingle | Zhenzhen Lu Ying Gao Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma Clinical and Experimental Obstetrics & Gynecology differentially expressed genes endometrial carcinoma insulin-like growth factor 1 polycystic ovary syndrome |
| title | Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma |
| title_full | Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma |
| title_fullStr | Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma |
| title_full_unstemmed | Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma |
| title_short | Searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma |
| title_sort | searching for biomarkers in the progression from polycystic ovary syndrome to endometrial carcinoma |
| topic | differentially expressed genes endometrial carcinoma insulin-like growth factor 1 polycystic ovary syndrome |
| url | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805180 |
| work_keys_str_mv | AT zhenzhenlu searchingforbiomarkersintheprogressionfrompolycysticovarysyndrometoendometrialcarcinoma AT yinggao searchingforbiomarkersintheprogressionfrompolycysticovarysyndrometoendometrialcarcinoma |