Virus and cell specific HMGB1 secretion and subepithelial infiltrate formation in adenovirus keratitis.

Virus and cell specific HMGB1 secretion and subepithelial infiltrate formation in adenovirus keratitis.

A highly contagious infection caused by human adenovirus species D (HAdV-D), epidemic keratoconjunctivitis (EKC) results in corneal subepithelial infiltration (SEI) by leukocytes, the hallmark of the infection. To date, the pathogenesis of corneal SEI formation in EKC is unresolved. HMGB1 (high-mobi...

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Bibliographic Details
Main Authors: Amrita Saha, Mohammad Mirazul Islam, Rahul Kumar, Ashrafali Mohamed Ismail, Emanuel Garcia, Rama R Gullapali, James Chodosh, Jaya Rajaiya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013184
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