Discovering molecular signatures in kidney transplant biopsies with borderline changes and isolated V-lesions: single-cell RNA-sequencing analysis of human blood and tissue Spatial transcriptomics

Discovering molecular signatures in kidney transplant biopsies with borderline changes and isolated V-lesions: single-cell RNA-sequencing analysis of human blood and tissue Spatial transcriptomics

Abstract Acute T cell-mediated rejection (TCMR) is one of the most important causes of kidney graft injury and loss; however, in-depth transcriptomic analyses of relevant tissues and circulating immune cells are limited. In this study, we conducted single-cell RNA sequencing (scRNA-seq) on periphera...

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Main Authors: Jeongin Song, Minji Kang, Yunyoung Jang, Christine Suh-Yun Joh, Ha Yeon Shin, Julia Young Baik, Hyun Seung Choi, Kyu Hong Kim, Seong Min Lee, Seung-Min Cha, Hyunah Ku, Ahram Han, Sang Il Min, Jongwon Ha, Kyung Chul Moon, Sehoon Park, Seung Seok Han, Hajeong Lee, Dong Ki Kim, Kook Hwan Oh, Kwon Wook Joo, Ji Hwan Moon, Chung-Gyu Park, Yon Su Kim, Seung Hee Yang, Hyun Je Kim, Yong Chul Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Kidney transplantation/Nephrology
Kidney allograft function/Dysfunction
Rejection
T cell mediated rejection
Borderline change
Translational research/Science
Online Access:https://doi.org/10.1038/s41598-025-05191-x
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